Table 1.
The characteristics and functions of different FGFR1 rearrangements and partner genes.
| Genotypic | Chromosome abnormality | Year | Fusion site (partner;FGFR1) | Breakpoint (partner;FGFR1) | Oligomeric/dimeric domain of the fusion | Function of partner genes |
|---|---|---|---|---|---|---|
| ZNF198-FGFR1(15) | t (8;13)(p11.2;q11-12) | 1998 | exon 17;exon 9 | exon 17;exon 9 | Five zinc fingers or proline-rich domain (16) | DNA repair (17) |
| FOP1-FGFR1 (18) | t(6;8)(q27;p11.2) | 1999 | exon 5/6/7;exon 9 | intron 6;intron 8 | The LisH motif (18) | Anchoring of centrosome (19) |
| CEP110-FGFR1 (20) | t(8;9)(p11-12;q32-34) | 2000 | exon 15;exon 9 | Intron x;exon 8 | Leucine zipper (20) | Regulation of mitosis and cell cycle (21) |
| HERVK-FGFR1 (22) | t(8;19)(p11.2;q13) | 2000 | Not clear | Not clear | Not clear | Proliferation, transformation and tumorigenesis of normal cells (23, 24) |
| BCR-FGFR1 (25) | t(8;22)(p11.2;q11.2) | 2001 | exon 4;exon 9 | intron 4;intron 8 | Serine/threonine kinase domain (26) | Critical regulators of brain development (26) |
| NUP98-FGFR1 (27) | t(8;11)(p11.2;p15) | 2001 | Not clear | Not clear | The coiled-coil domain (not clear) | Nucleo-cytoplasmic transport (28) |
| FOP2-FGFR1 (29) | ins(8;12)(p11.2;p11p22) | 2004 | exon 4;exon 9 | intron 4;intron 8 | First two coiled-coil domains(30) | Not clear |
| TIF1-FGFR1 (31) | t(7;8)(q34;p11.2) | 2005 | Not clear | intron 11;intron 9 | TRIM domain (31) | Transcription factor (32) |
| MYO18A-FGFR1 (33) | t(8;17)(p11.2;q25) | 2005 | exon 32;exon 9 | Controversial | Presumably PDZ domain (34) | Unconventional myosin (34) |
| CPSF6-FGFR1 (35) | t(8;12)(p11.2;q15) | 2008 | exon 8;exon 9 | intron 8;Not clear | RNA recognition motif (35) | 3’ cleavage and polyadenylation of pre-mRNA (36, 37) |
| LRRFIP1-FGFR1 (38) | t(2;8)(q37;p11.2) | 2009 | exon 9;exon 9 | Not clear | The coiled-coil domain (38) | Organism immune response |
| CUX1-FGFR1 (39) | t(7;8)(q22;p11.2) | 2011 | exon 11;exon 10 | Not clear | Not clear | Tumor suppressor (40) |
| TPR-FGFR1 (41) | t(1;8)(q25;p11.2) | 2012 | exon 22/23;exon 13 | intron 22;intron 12 | TprMet, NPC relavant domain (41, 42) | Nuclear pore protein (43) |
| NUP358-FGFR1 (44) | t(2;8)(q12;p11.2) | 2013 | exon 20;exon 9 | Not clear | Leucine zipper part (44) | Nucleo-cytoplasmic transport (45) |
| SQSTM1-FGFR1 (46) | t(5;8)(q35;p11.2) | 2014 | exon 9;exon 9 | intron 8;intron 8 | PB1 domain (46) | Regulating the activation of NF-κβ (46, 47) |
| TFG-FGFR1 (48) | t(3;8)(q12;p11.2) | 2020 | exon 8;exon 10 | Not clear | Not clear | Not clear |
| HOOK3-FGFR1 (49) | inv(8;8)(p11.23;p11.21) | 2022 | Not clear | exon 11;exon 10 | Not clear | Not clear |
The basic information about the FGFR1 rearrangements are based on studies currently present in the literature.