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. 2022 Nov 3;13:1055296. doi: 10.3389/fphar.2022.1055296

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Copyright © 2022 Chen, Wu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The molecular mechanisms and therapeutic targets of Chinese herbal medicine against DKD via suppressing oxidative stress and inflammation. FoxO3a, forkhead box transcription factor 3a; GSDMD, gasdermin D; NF-κB, nuclear factor-kappa B; NLRP3, NOD-like receptor thermal protein domain associated protein 3; Nrf2, nuclear factor-erythroid 2-related factor 2; PI3K, phosphoinositide 3-kinase; PP2A, protein phosphatase 2 A; ROCK, Rho-associated coiled-coil containing kinase; TLR4, toll-like receptor 4; TXNIP, thioredoxin-interacting protein.