Figure 3.

Least squares mean change in (a) MSIS-29 physical subscale, (b) MSIS-29 psychological subscale, and (c) MFIS-5 (MMRM analysis). One patient was excluded from the MMRM analysis because methylprednisolone was incorrectly recorded in the electronic case report form as a prior DMT. LS mean changes are estimated from mixed effects models with study visit as the time axis with adjustment for baseline scores; an unstructured correlation matrix was used to model within-person correlations.

BL: baseline; EOS: end of study; M: month; MSIS-29: Multiple Sclerosis Impact Scale-29; MFIS-5: Modified Fatigue Impact Scale-5; MMRM: mixed-effect model for repeated measures; DMT: disease-modifying therapy; LS: least square.