TABLE 4.

Associations of cytokine- and depression-related gene mutations with anatomic sites and TNM stage of melanoma.

Gene mutations	Anatomic site					TNM stage
	Acral (n = 98)		Non-acral (n = 53)		P-value	TNM stage 0–I (n = 75)		TNM stage II–IV (n = 76)		P-value
	Present	Absent	Present	Absent		Present	Absent	Present	Absent
Cytokine-related genes
IL-4	5	51	4	94	0.166	4	71	5	71	0.492
IL-5	2	52	1	97	0.282	2	73	1	75	0.505
IL-10	1	53	1	97	0.580	0	75	2	74	0.245
IL-12a	0	47	2	96	0.420	0	75	2	74	0.245
IL-12b	6	41	7	91	0.279	7	68	6	70	0.510
Depression-related genes
SLC6A4	26	72	12	34	0.375	25	50	13	63	†0.008
SLC6A3	38	60	19	51	0.431	30	45	27	49	0.272
HTR2A	5	93	2	34	0.529	2	73	5	71	0.216
DRD4	37	61	19	44	0.480	33	42	23	53	0.073
COMT	34	64	9	44	*0.016	18	57	25	51	0.128
TH	11	87	3	50	0.206	8	67	6	70	0.400
MAOA	13	85	11	42	0.166	14	61	10	66	0.264

^†P < 0.01; *P < 0.05 by using Fisher’s exact tests.