. 2022 Nov 3;13:1057932. doi: 10.3389/fimmu.2022.1057932

Table 1.

Molecular phenotype and regulatory signatures of human and mouse intestinal mesenchymal stromal cell subsets.

Spatial Distribution	Mouse			Human			Ref
	Cell Type Annotation	Marker (Lineage^-)	TF	Cell Type Annotation	Marker (Lineage^-)	TF
Lamina Propria	Rare PGE2 Producing Fibroblast (RPPF)	gp38⁺CD146^-CD140a^loCD34⁺ CD81^-CD90^lo/-FGFR2⁺	Runx2 Prdm1	Stromal 1	CD146^-CD90⁺ ADAMDEC1⁺	RUNX2 FOXF1/2	(16, 17, 20)
Lamina Propria	CD34⁺Pdgfra^lo Fibroblast	gp38⁺CD146^-CD140a^loCD34⁺CD81^-CD90^Hi	Isl1 Cebpa	Stromal 1	CD146^-CD90⁺ CCL11⁺	CEBPA	(17, 20)
Sub-epithelium	Telocyte (Intestinal Subepithelial Myofibroblast)	CD140a^Hi CD201⁺ Spon1⁺Foxl1⁺	Foxl1	Stromal 2a	CD146^-CD90^-CD142⁺CPM⁺	FOXL1	(8, 17, 20)
Sub-epithelium	Telocyte (Intestinal Subepithelial Myofibroblast)	CD140a^Hi CD201⁺ Foxl1⁺ Lgr5⁺Adamts18⁺	Foxl1	Stromal 2b	CD146^-CD90^-CD142⁺BMP7⁺	FOXL1	(17, 19, 20)
Underneath crypts, Submucosa	MRISC (Colon)	gp38⁺CD81⁺ CD90⁺CD34⁺ Rspo1⁺	Klf2 Ebf1	Stromal 3	CD146^-CD90⁺CD34⁺ CD73⁺ RSPO3⁺GREM1⁺	FOXP2	(13, 17, 20)
Underneath crypts, Submucosa	Trophocyte (SI)	gp38⁺CD81⁺ CD90^-CD34⁺ Grem1⁺	Klf2 Ebf1	Stromal 3	CD146^-CD90⁺CD34⁺ CD73⁺ RSPO3⁺GREM1⁺	FOXP2	(11, 17, 20)
Musculature	Myocyte	gp38⁺CD146⁺ Cd59a⁺Pcp4⁺	Mef2d Srf	Myocyte	CDH2^-CD146⁺a9b1⁺ MFAP5⁺	MEF2 SRF	(17, 20)

Lineage, EpCAM/CD45/CD31; TF, Transcription Factors.