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. 2022 Sep 16;50(7):858–866. doi: 10.1177/01926233221123523

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© The Author(s), 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Exercise training reverses aberrant myelopoiesis in obesity. In obesity, hematopoietic stem cell (HSC) differentiation skews toward myelopoiesis, resulting in an overproduction of pro-inflammatory myeloid lineage cells in circulation and HSC exhaustion. Exercise reverses these effects by promoting HSC maintenance and inhibiting aberrant myelopoiesis. Green lines indicate the effects of obesity and red lines indicate the effects of exercise. Figure created with BioRender.com.