Table 2. Drawbacks of transdermal patch.

Source [19].

Sr. No.	The drawbacks of transdermal delivery systems
1	Possible allergic reactions such as rashes, itching, swelling, etc. at the site where transdermal patches are applied.
2	Drugs with greater molecular sizes (over 1000) are more difficult to absorb.
3	There is variation in the skin's barrier function based on its location.
4	Transdermal patches are costlier when compared to tablets.