TABLE 2.
Identification results of significant differential metabolites in cell samples.
| Metabolites | VIP | p_value | FC | Log2FC | Type |
|---|---|---|---|---|---|
| (R)-2-hydroxystearic acid | 1.026262304 | 0.150466678 | 2.357333023 | 1.237155584 | up |
| N-Oleoylethanolamine | 1.794095424 | 0.003811691 | 0.382583326 | −1.386154097 | down |
| Uridine | 1.862551429 | 0.003392615 | 0.44267699 | −1.175673711 | down |
| D-Trehalose | 1.031047395 | 0.028538386 | 0.466447489 | −1.100213419 | down |
| Lactose | 1.031047395 | 0.028538386 | 0.466447489 | −1.100213419 | down |
| Lactulose | 1.031047395 | 0.028538386 | 0.466447489 | −1.100213419 | down |
| Maltose | 1.031047395 | 0.028538386 | 0.466447489 | −1.100213419 | down |
| 4-Guanidinobutyric Acid | 1.644191608 | 0.006362563 | 0.478042103 | −1.064790407 | down |
| Phenyllactate (Pla) | 1.174460381 | 0.022824344 | 0.484997939 | −1.043949478 | down |
| Uridine 5-Monophosphate | 1.176790122 | 0.162335978 | 0.463132865 | −1.110501956 | down |
| N-lactoyl-phenylalanine | 1.669737584 | 0.0098291 | 0.439787525 | −1.185121413 | down |
| D-Malic acid | 1.627669732 | 0.018114668 | 0.495722017 | −1.012396758 | down |
| 3-Methyluridine | 1.929564294 | 0.002227522 | 0.319995889 | −1.643874724 | down |
| 5-Hydroxy-2′-deoxyuridine | 1.862551429 | 0.003392615 | 0.44267699 | −1.175673711 | down |
| Gly-Gly | 1.571840697 | 0.002138695 | 0.430891368 | −1.214603899 | down |
| Adenosine 2′-Phosphate | 1.316383154 | 0.152484703 | 0.41634288 | −1.264155943 | down |
| L-Methionine | 1.776940312 | 0.00077552 | 0.492652152 | −1.021358735 | down |
| Asp-phe | 1.046400676 | 0.358657024 | 0.495944425 | −1.011749631 | down |
| 2′-Deoxyinosine | 1.532960767 | 0.00715507 | 0.452891979 | −1.142761107 | down |
| 2-Hydroxy-6-Aminopurine | 1.155758566 | 0.241141732 | 0.465095063 | −1.104402468 | down |
| Oleamide | 1.924806509 | 6.39059E-05 | 0.268566704 | −1.896647638 | down |
| Spermidine | 1.396948582 | 0.025423149 | 0.420968131 | −1.248217075 | down |
| FFA (20:1) | 1.727570459 | 0.002707229 | 0.265337637 | −1.914098766 | down |
| Gly-Phe | 1.13556765 | 0.212600373 | 0.447247405 | −1.160854984 | down |
| N-(2-hydroxyethyl)stearamide | 1.953727522 | 3.41233E-05 | 0.437311551 | −1.193266638 | down |
| 2,4-diacetamino-2,4,6-triphenoxy-D-mannopyranose | 1.071497895 | 0.281356736 | 0.492180041 | −1.022741941 | down |
| Guanine | 1.155758566 | 0.241141732 | 0.465095063 | −1.104402468 | down |
| Ala-Phe | 1.344414419 | 0.063840035 | 0.482970486 | −1.049993067 | down |
| Nicotinamide riboside (chloride) | 1.309922868 | 0.063146704 | 0.333891167 | −1.582550169 | down |
| (E,Z)-2-Amino-3,14-octadecadien-1-ol | 1.924806509 | 6.39059E-05 | 0.268566704 | −1.896647638 | down |
| Ile-Asp | 1.010367737 | 0.40221139 | 0.496493079 | −1.010154487 | down |
| Bis(2-ethylhexyl) phthalate | 1.887840954 | 0.000315942 | 0.456019919 | −1.132831253 | down |
| 1-O-Hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine | 1.498387225 | 0.015862398 | 0.497110428 | −1.008361728 | down |
| 1-Oleoyl-2-acetyl-sn-glycerol | 1.677918508 | 0.004816631 | 0.395767044 | −1.337276614 | down |
| 5alpha-cholest-8-en-3-one | 1.688626191 | 0.020456378 | 0.31539651 | −1.664761398 | down |
| Docosatrienoic acid | 1.779951599 | 0.007774672 | 0.331983542 | −1.590816375 | down |
| Lagocholic acid | 1.825654736 | 0.001145095 | 0.48324243 | −1.049180963 | down |
| Amastatin | 1.319838137 | 0.460739062 | 0.439074016 | −1.187463935 | down |
| Cidofovir | 1.089783659 | 0.351788917 | 0.478857045 | −1.062333067 | down |
| Macluraxanthone | 1.709475948 | 0.014630029 | 0.402322996 | −1.313573894 | down |
| 17-phenoxy trinor Prostaglandin F2 isopropyl ester | 1.876280492 | 0.003048513 | 0.283684516 | −1.817640687 | down |
| Arg Tyr Ser | 1.816846267 | 0.004637158 | 0.459449778 | −1.122020924 | down |
| Asp Ile Leu | 1.238714749 | 0.253675276 | 0.455604991 | −1.134144543 | down |
| Asp-Ile | 1.119726645 | 0.343004074 | 0.453756913 | −1.140008473 | down |
| Dihydro Isorescinnamine | 1.889098004 | 0.001158257 | 0.263593609 | −1.923612705 | down |
| Glu Asn Ile Ile Asp | 1.556418266 | 0.014100853 | 0.459065114 | −1.123229293 | down |
| Glu Glu Met Ile Ala | 1.299664555 | 0.076952867 | 0.458315081 | −1.125588337 | down |
| Hexadecyl Acetyl Glycerol | 1.881653456 | 1.20369E-05 | 0.425131424 | −1.234019195 | down |
| Huratoxin | 1.659772823 | 0.000270397 | 0.470711454 | −1.087085136 | down |
| Lys Ile Val Lys | 1.792448631 | 0.008780319 | 0.312597122 | −1.677623601 | down |
| N-dodecanoyl-L-Homoserine lactone-3-hydrazone-biotin | 1.796933647 | 0.000749497 | 0.499898179 | −1.000293823 | down |
| Neomycin C | 1.621473216 | 0.010855042 | 0.47575651 | −1.071704698 | down |
| Neurosporaxanthin;all-trans-Neurosporaxanthin | 1.423578723 | 0.033931325 | 0.139068695 | −2.846130392 | down |
| Phe Lys Thr Glu | 1.362690575 | 0.031184707 | 0.391329658 | −1.353543642 | down |
| Prephytoene diphosphate | 1.930776567 | 1.06291E-06 | 0.418528927 | −1.256600757 | down |
| R-4-benzyl-3-((R)-3-hydroxy-2,2-dimethyloctanoyl)-5,5-dimethyloxazolidin-2-one | 1.418030313 | 0.026251978 | 0.437099278 | −1.193967099 | down |
| Tyr Glu Gln Asp | 1.815469014 | 4.49847E-05 | 0.464389266 | −1.106593469 | down |
| (6S,7R,8R,11S,12S,15R,16R)-7-(hydroxymethyl)-7,12,16-trimethyl-15-[(2R)-6-methyl-5-methylideneheptan-2-yl]pentacyclo [9.7.0.01,3.03,8.012,16]octadecan-6-ol | 1.220343105 | 0.030324096 | 0.204957094 | −2.286606167 | down |
| [(2S)-2-pentadecanoyloxy-3-tetradecanoyloxypropyl] (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate | 1.008314167 | 0.009203128 | 0.378689054 | −1.400914373 | down |
| (2R,3R,4S,5S,6R)-2-[[(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 1.229648547 | 0.025360154 | 0.097710661 | −3.355340208 | down |