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. 2022 Nov 17;20(11):e07595. doi: 10.2903/j.efsa.2022.7595
RefID Source Author(s) Title Year
24 Literature Bozoğlan BK, Tunç S and Duman O Investigation of neohesperidin dihydrochalcone binding to human serum albumin by spectroscopic methods 2014
25 Literature Braune A, Engst W and Blaut M Degradation of Neohesperidin Dihydrochalcone by Human Intestinal Bacteria 2005
57 Literature Fang Y, Cao W, Xia M, Pan S and Xu X Study of structure and permeability relationship of flavonoids in Caco‐2 cells 2017
58 Literature Fang Y, Liang F, Liu K, Qaiser S, Pan S and Xu X Structure characteristics for intestinal uptake of flavonoids in Caco‐2 cells 2018
75 Literature Han GE, Kang H‐T, Chung S, Lim C, Linton JA, Lee J‐H, Kim W, Kim S‐H and Lee JH Novel neohesperidin dihydrochalcone analogue inhibits adipogenic differentiation of human adipose‐derived stem cells through the Nrf2 pathway 2018
95 Literature Johnston K, Sharp P, Clifford M and Morgan L Dietary polyphenols decrease glucose uptake by human intestinal Caco‐2 cells 2005
209 Literature Sjöstedt N, Deng F, Rauvala O, Tepponen T and Kidron H Interaction of Food Additives with Intestinal Efflux Transporters 2017
230 Literature Waalkens‐Berendsen DH, Kuilman‐Wahls MEM and Bär A Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats 2004
231 Literature Wang X, Pan Y, Ma J, Shi S, Zheng X and Xiang Z Application of a liquid chromatography‐tandem mass spectrometry method to the pharmacokinetics, bioavailability and tissue distribution of neohesperidin dihydrochalcone in rats 2014
286 Call for data Gumbmann MR, Gould DH, Robbins DJ and Booth AN (Documentation provided to EFSA nr: 9) Toxicity studies of neohesperidin dihydrochalcone 1978
306 Call for data Sequani Limited (Documentation provided to EFSA nr: 9) Neohesperidin dihydrochalcone: In Vitro mammalian cell micronucleus test 2018
307 Call for data (a) T.N.O. – Division for Nutrition and Food Research (Documentation provided to EFSA nr: 9) Sub‐chronic (90‐day) oral toxicity study with neohesperidine dihydrochalcone (NHDC) in rats 1986
339 Call for data/Reply to EFSA clarifications request Western Regional Research Laboratory (Documentation provided to EFSA nr: 10) Toxicity study of two flavanone dihydrochalcones (potential artificial sweetening agents) 1965
345 Literature Zhang FX, Yuan YL, Cui SS, Li M, Tan X, Qiu ZC and Li RM Dissection of the potential pharmacological function of neohesperidin dihydrochalcone – a food additive – by in vivo substances profiling and network pharmacology 2021
354 Literature Choi S, Yu S, Lee J and Kim W Effects of Neohesperidin Dihydrochalcone (NHDC) on Oxidative Phosphorylation, Cytokine Production, and Lipid Deposition 2021
360 Literature Shi ZJ, Lei HH, Chen G, Yuan PH, Cao Z, Ser HL, Zhu XH, Wu F, Liu CX, Dong MY, Song YC, Guo YY, Chen C, Hu KX, Zhu YF, Zeng XA, Zhou JL, Lu YJ, Patterson AD and Zhang LM Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice 2021
789 Call for data Bioneeds India Private Limited (Documentation provided to EFSA nr: 11) In vitro mammalian cell micronucleus test of neohesperidin DC in human lymphocytes 2022
(a)

This unpublished study report was subsequently published as Lina BAR, Dreef‐van der Meulen HC, Leegwater DC, 1990. Subchronic (13‐week) oral toxicity of neohesperidin dihydrochalcone in rats. Food Chemistry and Toxicology, 26(7), 507–513. https://doi.org/10.1016/0278-6915(90)90121-3.