Table 4.
Sensitivity analysis: Multivariate regressions (main effects only)
|
Variable
|
Estimate
|
SE
|
P
value
|
Estimate
|
SE
|
P
value
|
|
|
Complete model
|
|
|
Best model
|
|
|
| Mortality | ||||||
| Intercept | 3.63 | 3.27 | 0.268 | 4.39 | 3.22 | 0.173 |
| Creatinine | 1.59 × 10-3 | 1.37 × 10-3 | 0.246 | 1.99 × 10-3 | 1.32 × 10-3 | 0.132 |
| Bilirubin | 7.26 × 10-4 | 1.10 × 10-3 | 0.505 | - | - | - |
| INR | 3.49 × 10-1 | 2.15 × 10-1 | 0.104 | 3.47 × 10-1 | 2.12 × 10-1 | 0.101 |
| CRP | 3.27 × 10-3 | 3.10 × 10-3 | 0.292 | - | - | - |
| Leucocytes | 7.01 × 10-2 | 2.64 × 10-2 | 0.008 | 7.84 × 10-2 | 2.53 × 10-2 | 0.002 |
| HE 1-2 | -2.88 × 10-1 | 4.28 × 10-1 | 0.500 | -2.67 × 10-1 | 4.1 × 10-1 | 0.523 |
| HE 3-4 | 2.24 | 3.56 × 10-1 | < 0.001 | 2.26 | 3.50 × 10-1 | < 0.001 |
| Albumin | -9.61 × 10-2 | 2.76 × 10-2 | < 0.001 | -1.02 × 10-1 | 2.72 × 10-2 | < 0.001 |
| Sodium | -6.21 × 10-2 | 2.45 × 10-2 | 0.011 | -6.51 × 10-2 | 2.45 × 10-2 | 0.004 |
| Age | 1.22 × 10-4 | 4.24 × 10-5 | 0.004 | 1.16 × 10-4 | 4.04 × 10-5 | 0.004 |
| TIPS | -7.29 × 10-1 | 4.12 × 10-1 | 0.077 | -8.22 × 10-1 | 4.01 × 10-1 | 0.040 |
| ACLF | ||||||
| Intercept | -1.822 | 2.713 | 0.502 | -2.70 | 8.51 × 10-1 | 0.002 |
| Creatinine | -1.06 × 10-3 | 1.21 × 10-3 | 0.384 | - | - | - |
| Bilirubin | 2.81 × 10-3 | 9.50 × 10-4 | 0.003 | 2.99 × 10-3 | 8.69 × 10-4 | 0.001 |
| INR | 2.16 × 10-1 | 2.01 × 10-1 | 0.281 | - | - | - |
| CRP | 5.21 × 10-3 | 2.58 × 10-3 | 0.043 | 4.67 × 10-3 | 2.39 × 10-3 | 0.050 |
| Leucocytes | 6.28 × 10-3 | 2.43 × 10-2 | 0.780 | - | - | - |
| HE 1-2 | 1.22 × 10-1 | 3.06 × 10-1 | 0.690 | 1.47 × 10-1 | 3.02 × 10-1 | 0.627 |
| HE 3-4 | 1.62 | 3.01 × 10-1 | < 0.001 | 1.63 | 2.94 × 10-1 | < 0.001 |
| Albumin | -3.80 × 10-2 | 2.00 × 10-2 | 0.058 | -3.98 × 10-2 | 1.99 × 10-2 | 0.046 |
| Sodium | -1.03 × 10-2 | 1.98 × 10-2 | 0.603 | - | - | - |
| Age | 6.39 × 10-5 | 3.11 × 10-5 | 0.039 | 5.63 × 10-5 | 2.96 × 10-5 | 0.057 |
| TIPS | 5.17 × 10-1 | 2.64 × 10-1 | 0.050 | 4.39 × 10-1 | 2.55 × 10-1 | 0.085 |
Dependent variables were in-hospital mortality (upper panel) and any increase in acute on chronic liver failure grade (lower panel). The full models (left side) included all parameters used for propensity score matching as covariates. After stepwise backward elimination by Akaike information criterion, a model (best model, right side) was selected for each dependent variable. ACLF: Acute on chronic liver failure; TIPS: Transjugular intrahepatic portosystemic shunt.