Table 4.

Mediation analyses of predicted fat mass on SBP/DBP levels via lipid traits and FBG

Path*	Indirect effect#	Direct effect&	Total effect&	Mediation ratio,Ψ %
FM-TC-SBP	0.012 (–0.003 to 0.030)	0.085 (0.003–0.170)	0.097 (0.014–0.180)
FM-TG-SBP	0.015 (–0.009 to 0.039)	0.082 (–0.005 to 0.169)	0.097 (0.014–0.180)
FM-HDL-c-SBP	−0.036 (–0.064 to −0.010)	0.132 (0.045–0.022)	0.097 (0.014–0.180)	−37.1
FM-LDL-c-SBP	0.010 (–0.012 to 0.032)	0.087 (0.001–0.173)	0.097 (0.014–0.180)
FM-FBG-SBP	0.008 (0.001–0.021)	0.089 (0.005–0.172)	0.097 (0.014–0.180)	8.2
FM-TC-DBP	0.024 (0.007–0.044)	0.229 (0.137–0.322)	0.252 (0.161–0.344)	9.5
FM-TG-DBP	0.025 (0.001–0.048)	0.228 (0.133–0.323)	0.252 (0.161–0.344)	9.9
FM-HDL-c-DBP	−0.026 (–0.058 to 0.043)	0.278 (0.182–0.374)	0.252 (0.161–0.344)
FM-LDL-c-DBP	0.022 (–0.001 to 0.045)	0.231 (0.137–0.325)	0.252 (0.161–0.344)
FM-FBG-DBP	0.004 (–0.002 to 0.015)	0.249 (0.157–0.340)	0.252 (0.161–0.344)

FM, fat mass; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; FBG, fasting blood glucose.

^*Mediating effect models were constructed with predicted fat mass (In-transformed) as predictors, SBP/DBP (In-transformed) as dependent variable, and metabolic traits (In-transformed) as mediators adjusted for age, ethnicity, predicted lean body mass, dietary variety score, smoking status, drinking status, physical activity, family history of cardiovascular disease, family history of cancer.

^#Indirect effects were showed as beta coefficients and bias corrected 95% confidence intervals (95% BCCIs).

^&Direct and total effects were showed as beta coefficients (95% confidence intervals).

^ΨMediation ratio was calculated as (indirect effect/total effect) × 100.