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. 2022 Aug 9;42(12):2216–2229. doi: 10.1177/0271678X221119288

Figure 1.

Figure 1.

Mild TBI is undetectable by conventional MRI but induces long-term behavioural deficits. (a) Experimental design showing that two depths of impact (1.5 mm: mild TBI; 2 mm: moderate TBI) have been compared in the CCI model. (b) Representative T2-weighted (contusion) and T2*-weighted (hemorrhage) MRI acquisitions and corresponding quantifications 24 hours after mild or moderate TBI. n = 7/8 mice/group. *p < 0.05 vs mild TBI; **p < 0.01 vs mild TBI; ***p < 0.001 vs mild TBI, Mann-Whitney test; #p < 0.05 vs d0; ##p < 0.01 vs d0, Wilcoxon paired-test. Red arrows indicate the site of impact. (c) Measures of mouse weights 7 days before TBI, and day 0, 1, 7 and 21 days after TBI. (d) Schematic representation of Y maze behavioural test and quantifications of the percentage of entries in the new arm 7 days before and 7 and 21 days after mild or moderate TBI and (e) Representative sample traces and corresponding quantifications of the total distance moved, velocity, time of movement and time spend in the center on the open field test 7 days before, 7 and 21 days after mild or moderate TBI. n = 10 mice/group, #p < 0.05 vs new arm, Wilcoxon paired-test; ##p < 0.01 vs d-7 Wilcoxon paired-test.