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. 2022 Aug 9;42(12):2216–2229. doi: 10.1177/0271678X221119288

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Figure 4. — Immunohistochemistry analyses reveal long-lasting neuroinflammation induced by miTBI. (a and b) Long-lasting microgliosis induced by miTBI using Iba1 and CD68 immunostainings. (a) Cortical microgliosis. Representative photomicrographs of microglia and respective quantifications (a1) 7 days and (a2) 21 days after miTBI. (b) Hippocampal microgliosis. Representative photomicrographs of microglia and respective quantifications (b1) 7 days and (b2) 21 days after miTBI (c,d) Mild TBI provokes a long lasting astrogliosis. (a) GFAP positive astrocytes were found in the cortex 7 days after miTBI. (b) Astrocytes were found abundantly in the cortex 21 days after miTBI. (c) GFAP positive astrocytes were found abundantly in the hippocampus 7 days after miTBI. (d) Astrocytes were found in the hippocampus 21 days after miTBI. n = 6 mice/group, *p < 0.05, **p < 0.01 vs contralateral ROI, Wilcoxon paired-test.