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. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: Biochemistry. 2022 Sep 22;61(20):2221–2228. doi: 10.1021/acs.biochem.2c00342

Table 2.

MdG248 Hydrolysis in Free DNA and NCPs

substrate kHyd (10−6 s−1)a t1/2 (h) rel. t1/2b
free DNA 8.4 ± 0.2 23 ± 1
WT NCP 3.1 ± 0.1 62 ± 2 2.7
H2B-R26,27,30A 5.1 ± 0.1 38 ± 1 1.7
H2B-K24,25,28,31A 6.5 ± 0.1 30 ± 1 1.3
a

Values are the ave. ± std. dev. of three independent experiments.

b

Rel. t1/2 = t1/2 (NCP)/t1/2 (Free DNA).