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. 2022 Nov 17;12:19759. doi: 10.1038/s41598-022-23806-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Detailed complement profile of the MIS-C cohort before, during and after IVIG therapy, and of healthy controls. Levels of the complement pathway (classical-, lectin- and alternative) activities, factors (C1q, C4, C3, Factors D, B and properdin) and regulators (C1-inhibitor antigen and activity, Factors H and I) were determined in serum, whereas that of activation products (C1s-C1-inhibitor complex, MASP1-C1-inhibitor complex, C4a, C4d, C3a, Bb and sC5b-9) in EDTA plasma. Violin plots (with dashed horizontal lines indicating the median values, dotted lines indicating the quartiles) show results for the 18 healthy control children (HC), and for all MIS-C cases who had samples from acute stage, before IVIG treatment, or from stable remission after hospital discharge. P values for the pair-wise group comparisons (HC-acute and acute-remission groups) on the violin plots were calculated by the Mann–Whitney test. Non-significant differences are not marked, and p value symbols (*p < 0.05, **p < 0.01, ***p < 0.001) indicate significant results after 5% false discovery rate correction using the Benjamini–Hochberg method.