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. 2022 Nov 17;12:19759. doi: 10.1038/s41598-022-23806-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ranking of complement and macrophage measures as markers of acute MIS-C and therapy response (a): Cumulative frequencies (%) of MIS-C cases in acute (red, solid circles) or in remission (purple, open circles) stage, and of healthy controls (blue, open rhombus), plotted against the range of selected complement- and macrophage activation markers. (b): Performance of complement activation marker and neopterin levels to describe therapy responses in MIS-C (ROC-analysis). (c): Area under the curve (AUC) values with 95% confidence intervals.

Ranking of complement and macrophage measures as markers of acute MIS-C and therapy response (a): Cumulative frequencies (%) of MIS-C cases in acute (red, solid circles) or in remission (purple, open circles) stage, and of healthy controls (blue, open rhombus), plotted against the range of selected complement- and macrophage activation markers. (b): Performance of complement activation marker and neopterin levels to describe therapy responses in MIS-C (ROC-analysis). (c): Area under the curve (AUC) values with 95% confidence intervals.