TABLE 6.
Effects of KOR agonists on CPA, hypolocomotion and motor incoordination.
| KOR agonists | CPA | Inhibition of novelty-induced hyperlocomotion | Motor incoordination in the rotarod test |
| RB-64 (White et al., 2015) | Yes | No | No |
| Nalfurafine (20 μg/kg) (Liu et al., 2019) | No | No | Small but significant effect |
| 3-deoxyl nalfurafine (42B) (Chen et al., 2022a) | No | Yes | Yes |
| 16-Bromo Sal A (Paton et al., 2020) | No | No | ND |
| HS666 (Spetea et al., 2017) | No | No | ND |
| HS665 (Spetea et al., 2017) | Yes | No | ND |
| LOR17 (Bedini et al., 2020) | ND | No (in the hole-board test) | No |
ND, not determined.