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. 2022 Nov 17;12(11):e1113. doi: 10.1002/ctm2.1113

FIGURE 1.

FIGURE 1

SRSF11 is upregulated in CRC and clinically relevant to prognostic significance. (A and B) Relative expression of SRSF11 in paired colorectal cancer and matched normal tissue samples from (A) TCGA‐seq dataset (Mann–Whitney test, p < .0001). (B) Forty‐six pairs of colorectal cancer and matched normal tissue samples from the Affiliated Hospital of Xuzhou Medical University (paired t‐test, p = .0004). (C) IHC scores of SRSF11 in CRC tissue chip (N = 77; paired t‐test, p < .0001). (D) The representative IHC images of SRSF11 in three pairs of CRC tissues obtained from tissue chip. (E) WB analysis of the protein level of SRSF11 in normal colonic epithelial FHC cells and six malignant CRC cell lines (Kruskal–Wallis test, **p < .01). (F) Kaplan–Meier plots of CRC patients with high SRSF11 expression against low SRSF11 expression (log‐rank; OS, p = .004; PFS, p = .0001). OS, overall survival; PFS, progression‐free‐survival; CRC, colorectal cancer; TCGA, The Cancer Genome Atlas