Summary of findings 2. Summary of findings table ‐ Methylprednisolone compared to dexamethasone for hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19.

Methylprednisolone compared to dexamethasone for hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
Patient or population: hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19 Setting: inpatient, ICU Intervention: methylprednisolone Comparison: dexamethasone
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)	Comments
	Risk with dexamethasone	Risk with methylprednisolone
All‐cause mortality up to 30 days	357 per 1000	182 per 1000 (86 to 382)	RR 0.51 (0.24 to 1.07)	86 (1 RCT)	⊕⊝⊝⊝ Very lowa	The evidence is very uncertain about the effect of methylprednisolone on all‐cause mortality up to 30 days.
All‐cause mortality up to 120 days ‐ not reported	‐	‐	‐	‐	‐	No study reported this outcome.
Clinical improvement: discharged alive ‐ not reported	‐	‐	‐	‐	‐	No study reported this outcome.
Clinical worsening: new need for invasive mechanical ventilation or death ‐ not reported	‐	‐	‐	‐	‐	No study reported this outcome.
Serious adverse events ‐ not reported	‐	‐	‐	‐	‐	No study reported this outcome.
Adverse events ‐ not reported	‐	‐	‐	‐	‐	No study reported this outcome.
Hospital‐acquired infections ‐ not reported	‐	‐	‐	‐	‐	No study reported this outcome.
Invasive fungal infections ‐ not reported	‐	‐	‐	‐	‐	No study reported this outcome.
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.
See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_424391243004646489.

^a We downgraded one level for serious risk of bias for missing pre‐specification/protocol/statistical analysis plan and two levels for very serious imprecision (fewer than 50 events).