7. Characteristics of studies awaiting classification.

Study	Sponsor/developer	Design	Place of residence (World Bank 2021)	Population/disease severity	Setting	Drug	Route of administration	Number of participants	Status
EUCTR2020‐001333‐13‐FR	Groupe Hospitalier Paris Saint‐Joseph	RCT	High‐income country (France)	Included: patient diagnosed COVID positive by RT‐PCR and/or scanner (patients admitted with already mechanical ventilation and sedation, or with acute respiratory failure evolving very quickly)	Inpatient	Dexamethasone	IV	122	Prematurely ended
EUCTR2020‐001307‐16‐ES	Fundación para la Investigación Biomédica Hospital Ramón y Cajal	RCT	High‐income country (Spain)	ARDS	Inpatient	Methylprednisolone	IV	104	Prematurely ended
EUCTR2020‐001553‐48‐FR	Hospices Civils de Lyon	RCT	High‐income country (France)	Peripheral saturation by pulse oximeter SpO2 ≤ 94% in ambient air measured twice at 5‐ to 15‐min intervals, or PaO2/FiO2 < 300 mmHg	Inpatient	Prednisone	Oral	304	Prematurely ended
IRCT20081027001411N3	Teheran University of Medical Sciences	RCT	Middle‐income country (Iran)	Blood oxygen saturation < 93%; with ARDS	Inpatient	Prednisolone	Not stated	60	Completed
IRCT20120215009014N354	Hamedan University of Medical Sciences	RCT	Middle‐income country (Iran)	Hospitalised in ICU, bilateral pulmonary infiltration in chest X‐ray or CT‐scan; respiratory distress with > 24 breaths per minute	Inpatient	Hydrocortisone, methylprednisolone, dexamethasone	IV	81	Completed
IRCT20160118026097N4	Ghoum University of Medical Sciences	RCT	Middle‐income country (Iran)	Hypoxia requires supplemental oxygen to maintain oxygen saturation > 90%	Inpatient	Dexamethasone	Not stated	64	Completed
IRCT20200611047727N3	Shahid Beheshti University of Medical Sciences	RCT	Middle‐income country (Iran)	Oxygen saturation level < 93	Inpatient	Methylprednisolone	IV	60	Completed
IRCT20201015049030N1	Teheran University of Medical Sciences	RCT	Middle‐income country (Iran)	Blood oxygen saturation between 90% and 95%	Outpatient	Dexamethasone	Not stated	200	Completed
ISRCTN33037282	Clínica Medellín ‐ Grupo Quirónsalud	RCT	Middle‐income country (Colombia)	PaO2 ≤ 60 mmHg or SpO2 ≤ 90% or on HFNC, CPAP or NPPV at randomisation Excluded: on IMV	Inpatient	Methylprednisolone, dexamethasone	IV	680	Completed
NCT04244591	Peking Union Medical College Hospital	RCT	Middle‐income country (China)	PaO2/FiO2 < 200 mmHg; positive pressure ventilation (non‐invasive or invasive) or HFNC > 45 L/min for < 48 h; requiring ICU admission	Inpatient	Methylprednisolone	Not stated	80	Completed
NCT04325061	Dr. Negrin University Hospital	RCT	High‐income country (Spain)	Intubated and mechanically ventilated	Inpatient	Dexamethasone	IV	19	Terminated (lack of enrolment)
NCT04530409	ClinAmygate	RCT	Middle‐income country (Egypt)	Mild and moderate severity	Unclear	Dexamethasone	Unclear, most likely systemic	450	Completed
NCT04746430	General Practitioners Research Institute	RCT	High‐income country (Netherlands)	Exercise‐induced desaturation, defined as SpO2 < 92% (< 90% for COPD patients) and/or an absolute drop of ≥ 4% in SpO2 after a 1‐min sit‐to‐stand test or SpO2 < 92% (< 90% for COPD patients) at rest with GP's and patient's shared decision to keep patient at home despite this in itself being an indication for referral to hospital	Outpatient	Dexamethasone	Unclear, most likely systemic	2000	Terminated (too few patients)
EUCTR2020‐002186‐34‐ES	Fundació Hospital Universitari Vall d'Hebron ‐ Institut de Recerca (VHIR)	RCT	High‐income country (Spain)	Air oxygen saturation > 90 and < 94%; PaO2/FiO2 > 200 and ≤ 300 mmHg; Sa:FiO2 (O2 saturation measured with pulse oximeter/inspired O2 fraction) ≤ 350	Inpatient	Methylprednisolone	IV	100	Prematurely ended
EUCTR2020‐004323‐16	Azienda Ospedaliera Arcispedale Santa Maria Nuova/IRCCS di Reggio Emilia	RCT	High‐income country (Italy)	Need for supplemental oxygen in any delivery mode with the exception of IMV	Inpatient	Methylprednisolone	IV	260	Completed
NCT04347980	Centre Chirurgical Marie Lannelongue	RCT	High‐income country (France)	Admitted to ICU	Inpatient	Dexamethasone	IV	122	Terminated (ANSM (Agence nationale de sécurité du médicament et des produits de santé) Recommendation)
NCT04438980	Fundacion Miguel Servet	RCT	High‐income country (Spain)	Hospitalised Excluded: SpO2 < 90% (in air ambient) or PaO2 < 60 mmHg (in ambient air) or PaO2/FiO2 < 300 mmHg	Inpatient	Methylprednisolone	IV	72	Completed
NCT04451174	University of Chile	RCT	High‐income country (Chile)	Excluded: requirements of mechanical ventilation (IMV/NIV) Included: oxygen requirements until 35 % by Venturi mask or 5 L/min by nasal cannula	Inpatient	Prednisone	IV	184	Terminated (corticosteroid use approval)
Salukhov 2021	Not stated	RCT (unclear randomisation process)	Middle‐income country (Russia)	Moderate to severe course with process prevalence according to computed tomography without hypoxaemia (saturation SpO2 > 93%) with a duration of hyperthermia > 38 °C for 3 days or more and C‐reactive protein levels of 15 to 50 mg/L	Inpatient	Methylprednisolone	oral	40	Completed and published (but unclear randomisation process)
Ghanei 2021	Not stated	RCT	Middle‐income country (Iran)	Oxygen saturation (Spo2) less than 94%	Inpatient	Prednisolone	Not stated	236	Completed and published (not pre‐registered, no ethics vote named, no patient informed consent)
Gautam 2021	None	RCT	Middle‐income country (India)	Moderate to severe COVID‐19, oxygen saturation < 93% on room air	Inpatient	Methylprednisolone, dexamethasone	IV	140	Completed and published (not pre‐registered, no ethics vote named, no patient informed consent, no information about randomisation)
Montalvan 2021	Not stated	RCT (unclear randomisation process)	Middle‐income country (Honduras)	Not stated	Inpatient	Dexamethasone	Not stated	81	Completed and abstract published (no registration number, no information about randomisation process), only abstract available
Rashad 2021	South Valley University	RCT (unclear randomisation process)	Middle‐income country (Egypt)	Moderate to severe ≥ 5	Inpatient	Dexamethasone	IV	149	Completed and published (no pre‐registration, unclear randomisation process)
ARDS: acute respiratory distress syndrome; COPD: chronic obstructive pulmonary disease; CT: computed tomography; HFNC: high‐flow nasal cannula;ICU: intensive care unit; RCT: randomised controlled trial; RT‐PCR: reverse transcription polymerase chain reaction.