8. Sensitivity analyses for the comparison: systemic corticosteroids plus standard care versus standard care (plus/minus placebo).
Outcome | Main analyses | Risk of bias (excluding studies at high risk of bias) | Fixed‐effect model or random‐effects model | Preprint (excluding preprints) | Platform trial (excluding platform trialsa) |
All‐cause mortality up to 30 days | RR 0.90, 95% CI 0.84 to 0.97; 9 studies, 7898 participants | There were no RCTs with high risk of bias concerning this outcome | RR 0.90, 95% CI 0.83 to 0.97; 9 studies, 7898 participants | There were no RCTs as a preprint concerning this outcome | RR 0.94, 95% CI 0.82 to 1.08; 7 studies, 1094 participants |
All‐cause mortality up to 120 days | RR 0.74, 95% CI 0.23 to 2.34; 3 studies, 485 participants | There were no RCTs with high risk of bias concerning this outcome | RR 0.92, 95% CI 0.73 to 1.15; 3 studies, 485 participants | There were no RCTs as a preprint concerning this outcome | There were no platform trials concerning this outcome |
Clinical improvement: discharged alive | RR 1.07, 95% CI 1.03 to 1.11; 3 studies, 6786 participantsb | There were no RCTs with high risk of bias concerning this outcome | RR 1.36, 95% CI 0.95 to 1.96; 3 studies, 6786 participantsc | There were no RCTs as a preprint concerning this outcome | RR 1.65, 95% CI 1.23 to 2.21; 2 studies, 361 participants |
aExcluding platform trials: Angus 2020; Horby 2021.
bUsing the fixed‐effect model.
c Using the random‐effects model.
CI: confidence interval; RR: risk ratio