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. 2022 Nov 17;2022(11):CD014963. doi: 10.1002/14651858.CD014963.pub2

8. Sensitivity analyses for the comparison: systemic corticosteroids plus standard care versus standard care (plus/minus placebo).

Outcome Main analyses Risk of bias (excluding studies at high risk of bias) Fixed‐effect model or random‐effects model Preprint (excluding preprints) Platform trial (excluding platform trialsa)
All‐cause mortality up to 30 days RR 0.90, 95% CI 0.84 to 0.97; 9 studies, 7898 participants There were no RCTs with high risk of bias concerning this outcome RR 0.90, 95% CI 0.83 to 0.97; 9 studies, 7898 participants There were no RCTs as a preprint concerning this outcome RR 0.94, 95% CI 0.82 to 1.08; 7 studies, 1094 participants
All‐cause mortality up to 120 days RR 0.74, 95% CI 0.23 to 2.34; 3 studies, 485 participants There were no RCTs with high risk of bias concerning this outcome RR 0.92, 95% CI 0.73 to 1.15; 3 studies, 485 participants There were no RCTs as a preprint concerning this outcome There were no platform trials concerning this outcome
Clinical improvement: discharged alive RR 1.07, 95% CI 1.03 to 1.11; 3 studies, 6786 participantsb There were no RCTs with high risk of bias concerning this outcome RR 1.36, 95% CI 0.95 to 1.96; 3 studies, 6786 participantsc There were no RCTs as a preprint concerning this outcome RR 1.65, 95% CI 1.23 to 2.21; 2 studies, 361 participants

aExcluding platform trials: Angus 2020Horby 2021.

bUsing the fixed‐effect model.

c Using the random‐effects model.

CI: confidence interval; RR: risk ratio