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. 2022 Nov 17;2022(11):CD014963. doi: 10.1002/14651858.CD014963.pub2

Comparison 7. Subgroup analysis: high‐income countries versus low‐ and middle‐income countries for the comparison of corticosteroids plus standard care versus standard care (plus/minus placebo) for hospitalised individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
7.1 All‐cause mortality up to 30 days 9 7898 Risk Ratio (M‐H, Random, 95% CI) 0.90 [0.84, 0.97]
7.1.1 High‐income countries 5 7047 Risk Ratio (M‐H, Random, 95% CI) 0.89 [0.81, 0.97]
7.1.2 Low‐ and middle‐income countries 4 851 Risk Ratio (M‐H, Random, 95% CI) 0.95 [0.82, 1.09]
7.2 All‐cause mortality up to 120 days 3 485 Risk Ratio (M‐H, Random, 95% CI) 0.74 [0.20, 2.75]
7.2.1 High‐income countries 1 30 Risk Ratio (M‐H, Random, 95% CI) 2.62 [0.63, 10.98]
7.2.2 Low‐ and middle‐income countries 2 455 Risk Ratio (M‐H, Random, 95% CI) 0.42 [0.06, 3.04]
7.3 Clinical improvement: discharged alive 3 6786 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [1.03, 1.11]
7.3.1 High‐income country 1 6425 Risk Ratio (M‐H, Fixed, 95% CI) 1.06 [1.02, 1.10]
7.3.2 Low‐ and middle‐income country 2 361 Risk Ratio (M‐H, Fixed, 95% CI) 1.65 [1.23, 2.21]