ACTRN12621001603808.

Study name	The effect of prednisolone vs dexamethasone on Covid‐19 in pregnancy: an open labelled randomised control trial
Methods	Trial design: open‐label, randomised controlled trial Sample size: 192 Setting: inpatient Language: English Number of centres: 1 Type of intervention (treatment/prevention): treatment
Participants	Inclusion criteria: women aged 18 to 50 years, pregnant > 16 weeks with COVID‐19, hospitalised with an oxygen requirement Co‐morbidities are included, not limited to obesity, hypertension, diabetes, pre‐existing illnesses Exclusion criteria: pregnancy < 16 weeks gestation, not requiring oxygen, contraindications to receiving corticosteroids
Interventions	Details of intervention: prednisolone Dose: 50 mg once per day for up to 10 days Route of administration: oral Treatment details of control group (e.g. dose, route of administration): dexamethasone, dose and route of administration not explicitly explained Concomitant therapy: not stated
Outcomes	Primary study outcome: WHO ordinal scale of clinical improvement compared at day 5 and at day 10
Starting date	1 December 2021
Contact information	Dr Carole‐Anne Whigham, Monash Health 246 Clayton Road Clayton 3168 Vic, Australia Phone: +61 404644029 Email: carole‐anne.whigham@monashhealth.org
Notes	Recruitment status: not yet recruiting Prospective completion date: not stated Date last update was posted: 24 November 2021 Sponsor/funding: Monash Health Hospital Victoria, Australia