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. 2022 Nov 17;2022(11):CD014963. doi: 10.1002/14651858.CD014963.pub2

Risk of bias for analysis 6.1 All‐cause mortality up to 30 days.

Study Bias
Randomisation process Deviations from intended interventions Missing outcome data Measurement of the outcome Selection of the reported results Overall
Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement
Subgroup 6.1.1 White
Corral‐Gudino 2021 Some concerns We judged the domain some concerns due to missing information about the allocation concealment. Low risk of bias Open‐label design (participants and clinicians were aware of the assigned treatment). ITT data presented. Low risk of bias No substantial data missing. Low risk of bias Both groups were measured at the same time and the measurements were similar between groups. Some concerns Outcome was registered in Eudra‐CT as in‐hospital mortality but reported as 28‐day‐mortality in the supplemental material. Some concerns Overall judged some concerns due to selection of reported results and missing information about the allocation concealment.
Horby 2021 Low risk of bias Randomisation was performed with the use of a web‐based system with concealment of the trial‐group assignment. No baseline differences between the groups. Some concerns 8% of the participants in the control group received dexamethasone. Low risk of bias 6425 participants were randomised and 6425 were analysed. Low risk of bias Both groups were measured at the same time. The measurements were similar between groups. Low risk of bias Protocol and statistical plan available. Some concerns Overall judged some concerns due to deviations from the intended intervention in the control group.
Subgroup 6.1.2 Black, Asian or minority ethnic group
Horby 2021 Low risk of bias Randomisation was performed with the use of a web‐based system with concealment of the trial‐group assignment. No baseline differences between the groups. Some concerns 8% of the participants in the control group received dexamethasone. Low risk of bias 6425 participants were randomised and 6425 were analysed. Low risk of bias Both groups were measured at the same time. The measurements were similar between groups. Low risk of bias Protocol and statistical plan available. Some concerns Overall judged some concerns due to deviations from the intended intervention in the control group.
Subgroup 6.1.3 Unknown
Horby 2021 Low risk of bias Randomisation was performed with the use of a web‐based system with concealment of the trial‐group assignment. No baseline differences between the groups. Some concerns 8% of the participants in the control group received dexamethasone. Low risk of bias 6425 participants were randomised and 6425 were analysed. Low risk of bias Both groups were measured at the same time. The measurements were similar between groups. Low risk of bias Protocol and statistical plan available. Some concerns Overall judged some concerns due to deviations from the intended intervention in the control group.