| Study |
Bias |
| Randomisation process |
Deviations from intended interventions |
Missing outcome data |
Measurement of the outcome |
Selection of the reported results |
Overall |
| Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
Authors' judgement |
Support for judgement |
| Maskin 2021 |
Low risk of bias |
No issues with randomisation. |
Some concerns |
Minor issues with appropriate analysis but no relevant number of deviations or exclusions from analysis. |
High risk of bias |
Missing adjustment for competing risk of death in a trial with relevant death rate. |
Low risk of bias |
No issues with measurement. |
Low risk of bias |
No relevant issues with reporting |
High risk of bias |
High risk of bias due to missing adjustment for competing risk of death in domain 3. |
| Munch 2021b |
Low risk of bias |
No issues with randomisation process. |
Low risk of bias |
No issues with deviations from intended interventions |
High risk of bias |
Few, balanced, and blinded exclusions for similar reasons in both arms. Missing adjustment for competing risk of death. |
Low risk of bias |
No issues with measurement |
Low risk of bias |
No extraordinary issues with potential selection. |
High risk of bias |
High risk of bias due to missing adjustment for competing risk of death. |
