Risk of bias for analysis 9.5 Adverse events.

Study

Bias

Randomisation process

Deviations from intended interventions

Missing outcome data

Measurement of the outcome

Selection of the reported results

Overall

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Authors' judgement

Support for judgement

Maskin 2021

Low risk of bias

No issues with randomisation.

Some concerns

Minor issues with appropriate analysis but no relevant number of deviations or exclusions from analysis.

High risk of bias

Missing adjustment for competing risk of death in a trial with relevant death rate.

Low risk of bias

No issues with measurement.

Low risk of bias

No relevant issues with reporting.

High risk of bias

High risk of bias due to missing adjustment for competing risk of death in domain 3.