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. 2022 Nov 17;2022(11):CD014963. doi: 10.1002/14651858.CD014963.pub2

Risk of bias for analysis 11.1 All‐cause mortality up to 30 days.

Study Bias
Randomisation process Deviations from intended interventions Missing outcome data Measurement of the outcome Selection of the reported results Overall
Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement
Subgroup 11.1.1 <70 years
Maskin 2021 Low risk of bias No issues with randomisation. Some concerns Minor issues with deviations (2/51 patients from the control received not intended intervention) and appropriate analysis. Low risk of bias No relevant amount of missing data. Low risk of bias No relevant issues with measurement. Low risk of bias No relevant issues with reporting. Some concerns Some minor concerns regarding deviations in about 5% of patients and their exclusion from analysis.
Munch 2021b Low risk of bias No issues with randomisation process. Low risk of bias No issues with deviations from intended interventions Low risk of bias We requested data from the authors. Few, balanced, and blinded exclusions for similar reasons in both arms. Low risk of bias No issues with measurement Low risk of bias No issues with potential selection. Low risk of bias Low risk of bias in all domains.
Subgroup 11.1.2 ≥ 70 years
Maskin 2021 Low risk of bias No issues with randomisation. Some concerns Minor issues with deviations (2/51 patients from the control received not intended intervention) and appropriate analysis. Low risk of bias No relevant amount of missing data. Low risk of bias No relevant issues with measurement. Low risk of bias No relevant issues with reporting. Some concerns Some minor concerns regarding deviations in about 5% of patients and their exclusion from analysis.
Munch 2021b Low risk of bias No issues with randomisation process. Low risk of bias No issues with deviations from intended interventions Low risk of bias We requested data from the authors. Few, balanced, and blinded exclusions for similar reasons in both arms. Low risk of bias No issues with measurement Low risk of bias No issues with potential selection. Low risk of bias Low risk of bias in all domains.