Table 1.

Summary of clinical and histopathological characteristics of the 838 pT3N0-3M0 esophageal squamous cell carcinoma patients, the 5-year (5-yr), 10-year (10-yr) overall survival (OS) rate (%) and the 3-year (3-yr), 5-year (5-yr) disease-free survival (DFS) rate (%)

Characteristic		N (%)	5-yr OS (%)	10-yr OS (%)	P value	3-yr DFS (%)	5-yr DFS (%)	P value
Sex	Male	672(80.2)	45.7	39.9	0.881	46.2	40.9	0.704
	Female	166(19.8)	44.5	33.3		49.4	37.5
Age (years)	≤ 60	464(55.4)	48.9	44.2	0.007	50.3	44.0	0.029
	> 60	374(44.6)	41.2	31.7		42.5	35.3
Tumor location	Upper thoracic	119(14.2)	47.6	39.6	0.694	49.6	41.9	0.893
	Middle thoracic	486(58.0)	45.9	41.7		46.8	40.2
	Lower thoracic	233(27.8)	43.7	33.3		45.6	39.2
Degree of differentiation	Well	376(44.9)	49.1	41.8	0.001	53.1	44.9	< 0.001
	Moderate	392(46.8)	44.8	37.6		43.5	37.9
	Poor	70(8.4)	29.9	27.8		32.6	27.9
LVI	No	392(46.8)	55.9	48.5	< 0.001	57.7	50.9	< 0.001
	Yes	446(53.2)	36.4	29.7		37.5	30.9
PNI	No	317(37.8)	54.3	46.2	< 0.001	55.5	48.0	0.001
	Yes	521(62.2)	40.1	34.0		41.5	35.3
pN	N0	405(48.3)	61.6	52.6	< 0.001	63.8	56.1	< 0.001
	N1	238(28.4)	40.3	34.2		41.1	34.6
	N2	140(16.7)	21.1	16.9		22.6	16.9
	N3	55(6.6)	13.7	13.7		9.0	6.8
CRM CAP criteria	R0	779(93.0)	47.2	39.8	< 0.001	48.5	41.6	< 0.001
	R1	59(7.0)	22.9	22.9		26.0	20.8
CRM RCP criteria	R0	521(62.2)	50.6	44.2	< 0.001	51.4	44.8	0.001
	R1	317(37.8)	37.0	29.3		39.3	32.5
CRM three-tier criteria	> 1 mm	521 (62.2)	50.6	44.2	< 0.001	51.4	44.8	< 0.001
	0-1 mm	258(30.8)	40.3	30.6		42.4	35.2
	0 mm	59 (7.0)	22.9	22.9		26.0	20.8
Adjuvant therapy	No	613(73.2)	50.1	41.4	< 0.001	44.9	38.4	< 0.001
	Yes	225(26.8)	33.2	27.5		27.0	24.8
Extranodal invasion	No	207(47.8)	37.8	30.8	< 0.001	38.5	32.3	< 0.001
	Yes	226(52.2)	24.3	21.7		24.6	19.2

CAP College of American Pathologists, CRM Circumferential resection margin, LVI Lymphovascular invasion, RCP Royal College of Pathologists, PNI Perineural invasion