Table 2.
Univariate and Multivariate Cox proportional hazards analysis of various prognostic factors and their relationship to overall survival
| Univariate | Multivariate (CAP) | Multivariate (RCP) | Multivariate (three-tier criteria) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | Male/Female | 0.983(0.783–1.233) | 0.882 | ||||||
| Age (years) | ≤ 60/ > 60 | 1.285(1.069–1.545) | 0.007 | 1.017(1.006–1.028) | 0.002 | 1.018(1.007–1.029) | 0.001 | 1.018(1.007–1.029) | 0.001 |
| Tumor location | Upper thoracic | 1 | |||||||
| Middle thoracic | 0.995(0.756–1.312) | 0.974 | |||||||
| Lower thoracic | 1.086(0.806–1.464) | 0.586 | |||||||
| Degree of differentiation | Well and Moderate/Poor | 1.656(1.231–2.228) | 0.001 | 1.353(1.000–1.832) | 0.050 | 1.400(1.037–1.890) | 0.028 | 1.357(1.003–1.836) | 0.048 |
| LVI | No/Yes | 1.724(1.426–2.084) | < 0.001 | 1.200(0.977–1.473) | 0.082 | 1.206(0.983–1.479) | 0.073 | 1.189(0.969–1.460) | 0.098 |
| PNI | No/Yes | 1.500(1.233–1.825) | < 0.001 | 1.226(1.001–1.502) | 0.049 | 1.212(0.989–1.485) | 0.064 | 1.211(0.988–1.484) | 0.065 |
| pN | N0 | 1 | 1 | 1 | 1 | ||||
| N1 | 1.783(1.420–2.237) | < 0.001 | 1.697(1.338–2.151) | < 0.001 | 1.625(1.282–2.060) | < 0.001 | 1.673(1.319–2.123) | < 0.001 | |
| N2 | 3.219(2.519–4.114) | < 0.001 | 2.820(2.160–3.681) | < 0.001 | 2.721(2.084–3.553) | < 0.001 | 2.759(2.112–3.605) | < 0.001 | |
| N3 | 4.536(3.248–6.334) | < 0.001 | 3.727(2.615–5.311) | < 0.001 | 3.756(2.632–5.361) | < 0.001 | 3.694(2.590–5.268) | < 0.001 | |
| CRM CAP criteria | R0/R1 | 2.107(1.543–2.877) | < 0.001 | 1.814(1.321–2.492) | < 0.001 | ||||
| CRM RCP criteria | R0/R1 | 1.517(1.260–1.826) | < 0.001 | 1.295(1.072–1.564) | 0.007 | ||||
| CRM three-tier criteria | > 1 mm | 1 | 1 | ||||||
| 0-1 mm | 1.378(1.128–1.683) | 0.002 | 1.185(0.968–1.452) | 0.100 | |||||
| 0 mm | 2.350(1.706–3.238) | < 0.001 | 1.933(1.394–2.680) | < 0.001 | |||||
| Adjuvant therapy | No/Yes | 1.467(1.205–1.785) | < 0.001 | 1.072(0.869–1.323) | 0.516 | 1.079(0.875–1.331) | 0.478 | 1.073(0.870–1.324) | 0.511 |
| Extranodal invasiona | No/Yes | 1.518(1.206–1.912) | < 0.001 | ||||||
CAP College of American Pathologists, CRM Circumferential resection margin, LVI Lymphovascular invasion, RCP Royal College of Pathologists, PNI Perineural invasion
a This factor related to prognosis were not examined in the multivariate analysis