Table 3.
Univariate and Multivariate Cox proportional hazards analysis of various prognostic factors and their relationship to disease-free survival
| Univariate | Multivariate (CAP) | Multivariate (RCP) | Multivariate (three-tier criteria) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | Male/Female | 0.960(0.775–1.188) | 0.707 | ||||||
| Age (years) | ≤ 60/ > 60 | 1.213(1.018–1.446) | 0.031 | 1.015(1.005–1.026) | 0.003 | 1.015(1.005–1.026) | 0.003 | 1.015(1.005–1.026) | 0.003 |
| Tumor location | Upper thoracic | 1 | |||||||
| Middle thoracic | 1.031(0.793–1.341) | 0.818 | |||||||
| Lower thoracic | 1.068(0.801–1.423) | 0.655 | |||||||
| Degree of differentiation | Well and Moderate/ Poor | 1.556(1.161–2.085) | 0.003 | 1.276(0.947–1.718) | 0.109 | 1.306(0.971–1.757) | 0.078 | 1.275(0.946–1.717) | 0.110 |
| LVI | No/Yes | 1.733(1.447–2.077) | < 0.001 | 1.248(1.025–1.518) | 0.027 | 1.261(1.037–1.534) | 0.020 | 1.245(1.022–1.515) | 0.029 |
| PNI | No/Yes | 1.363(1.132–1.640) | 0.001 | 1.079(0.890–1.308) | 0.438 | 1.072(0.884–1.299) | 0.482 | 1.076(0.887–1.305) | 0.458 |
| pN | N0 | 1 | 1 | 1 | 1 | ||||
| N1 | 1.813(1.462–2.247) | < 0.001 | 1.667(1.331–2.087) | < 0.001 | 1.615(1.290–2.023) | < 0.001 | 1.660(1.324–2.080) | < 0.001 | |
| N2 | 3.021(2.389–3.821) | < 0.001 | 2.581(1.998–3.335) | < 0.001 | 2.531(1.957–3.272) | < 0.001 | 2.565(1.983–3.319) | < 0.001 | |
| N3 | 4.882(3.529–6.753) | < 0.001 | 3.900(2.760–5.512) | < 0.001 | 3.852(2.721–5.452) | < 0.001 | 3.881(2.744–5.489) | < 0.001 | |
| CRM CAP criteria | R0/R1 | 1.803(1.331–2.443) | < 0.001 | 1.575(1.157–2.145) | 0.004 | ||||
| CRM RCP criteria | R0/R1 | 1.362(1.140–1.627) | 0.001 | 1.130(0.942–1.355) | 0.189 | ||||
| CRM three-tier criteria | > 1 mm | 1 | 1 | ||||||
| 0-1 mm | 1.255(1.036–1.521) | 0.020 | 1.044(0.859–1.270) | 0.664 | |||||
| 0 mm | 1.945(1.424–2.655) | < 0.001 | 1.601(1.166–2.199) | 0.004 | |||||
| Adjuvant therapy | No/Yes | 1.617(1.340–1.952) | < 0.001 | 1.216(0.996–1.485) | 0.055 | 1.231(1.009–1.503) | 0.041 | 1.216(0.996–1.485) | 0.055 |
| Extranodal invasiona | No/Yes | 1.556(1.247–1.943) | < 0.001 | ||||||
CAP College of American Pathologists, CRM Circumferential resection margin, LVI Lymphovascular invasion, RCP Royal College of Pathologists, PNI Perineural invasion
a This factor related to prognosis were not examined in the multivariate analysis