Table 5.

CRM status and survival adjusted for lymph node status

		N0		N1-2		N3
		HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
OS
CAP criteria	R1 vs. R0	1.846(1.067–3.196)	0.029	2.511(1.645–3.835)	< 0.001	1.367(0.576–3.246)	0.478
RCP criteria	R1 vs. R0	1.874(1.366–2.570)	< 0.001	1.122(0.874–1.441)	0.366	1.499(0.830–2.705)	0.179
CRM three-tier criteria	0 mm vs. 0-1 mm	1.236(0.686–2.228)	0.481	2.521(1.590–3.996)	< 0.001	1.112(0.437–2.833)	0.824
	0 mm vs. > 1 mm	2.208(1.258–3.876)	0.006	2.483(1.608–3.835)	< 0.001	1.596(0.642–3.967)	0.314
	0-1 mm vs. > 1 mm	1.801(1.283–2.529)	0.001	0.970(0.741–1.270)	0.825	1.468(0.776–2.777)	0.238
DFS
CAP criteria	R1 vs. R0	1.615(0.952–2.740)	0.076	1.936(1.271–2.949)	0.002	1.369(0.611–3.071)	0.446
RCP criteria	R1 vs. R0	1.735(1.287–2.339)	< 0.001	0.956(0.751–1.218)	0.716	1.196(0.676–2.115)	0.538
CRM three-tier criteria	0 mm vs. 0-1 mm	1.120(0.634–1.979)	0.695	2.126(1.345–3.359)	0.001	1.266(0.523–3.067)	0.601
	0 mm vs. > 1 mm	1.884(1.097–3.232)	0.022	1.820(1.184–2.800)	0.006	1.440(0.613–3.380)	0.403
	0-1 mm vs. > 1 mm	1.700(1.233–2.345)	0.001	0.845 (0.651–1.097)	0.205	1.123(0.604–2.088)	0.714

CAP College of American Pathologists, CRM Circumferential resection margin, RCP Royal College of Pathologists