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. 2022 Nov 17;22:1184. doi: 10.1186/s12885-022-10302-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — CX3CL1 inhibits ccRCC cell proliferation, migration, and invasion by inducing ferroptosis in vitro. A 786-O cells were incubated with Fer-1 (0, 1, 2, 4 μM/ml) for 48, 72, 96, and 120 h; then, cell viability was estimated by CCK-8 assay, and cell proliferation of 786-O cells in normal control, OE-CX3CL1, and OE-CX3CL1 + Fer-1 groups was estimated by CCK-8 assay. B Cell colonies of 786-O cells in normal control, OE-CX3CL1, and OE-CX3CL1 + Fer-1 groups. C-D 786-O cell migration and invasion assays were performed in normal control, OE-CX3CL1, and OE-CX3CL1 + Fer-1 groups. E Western blotting of CX3CL1, PCNA, GPX4, and XCT proteins. F The immunostaining assay identified the subcellular localizations of CX3CL1, PCNA, GPX4, and XCT. Scale bar: 10 μm. *P < 0.05, **P < 0.01, ***P < 0.001