Table 4.

Univariate Cox regression analysis. HR > 1 indicates a greater risk for the group > 70y; HR < 1 indicates a smaller risk for the group > 70y

Parameter	OS HR [95% CI]	p-value	PFS HR [95% CI]	p-value
Treatment Regimen (nCRT vs. dRCT)	0.399 [0.203; 0.785]	0.008	0.477 [0.252; 0.902]	0.023
Age > 70 y vs. $\le$ 70 y)	0.850 [0.433; 1.666]	0.636	0.891 [0.493; 1.610]	0.701
Sex
(Female > 70 y vs. $\le$ 70 y)	0.782 [0.205; 2.982]	0.719	0.605 [0.168; 2.173]	0.441
(Male > 70 y vs. $\le$ 70 y)	0.773 [0.340; 1.759]	0.539	1.032 [0.511; 2.083]	0.931
ECOG (2–3 vs. 0–1)	3.825 [1.738; 8.416]	< 0.001	3.096 [1.460; 6.565]	0.003
T-stage (> 70 y vs. $\le$ 70 y)
T3	0.958 [0.429; 2.140]	0.917	0.973 [0.496; 1.908]	0.936
Grading (> 70 y vs. $\le$ 70 y)
G2	0.379 [0.133; 1.081]	0.070	0.487 [0.204; 1.164]	0.105
G3	2.328 [0.819; 6.619]	0.113	2.585 [1.025; 6.520]	0.044
Histology ($>$ 70 y vs. $\le$ 70 y)
SCC	0.462 [0.174; 1.227]	0.121	0.454 [0.172; 1.193]	0.109
AC	1.968 [0.625; 6.197]	0.248	1.495 [0.632; 3.536]	0.360

HR Hazard ratio, CI Confidence interval, OS Overall survival, PFS Progression-free survival, y years