TABLE 2.
AUC (with 95% CI), Youden index, specificity, and sensitivity in ROC of AI/group of junior ophthalmologists (OP1)/group of senior ophthalmologists (OP2) compared to the group of retinal specialists (OP3, as the golden standard).
| AI vs. OP3 | OP1 vs. OP3 | OP2 vs. OP3 | p (AUC, AI–OP3 vs. OP1–OP3) | p (AUC, AI–OP3 vs. OP2–OP3) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | 95% CI | p | Youden index | Sensitivity (%) |
Specificity (%) |
AUC | 95% CI | p | AUC | 95% CI | p | ||||||
| PED | 0.985 | 0.974–0.992 | <0.0001 | 0.9391 | 97.62 | 96.29 | 0.643 | 0.610–0.675 | 0.0001 | 0.808 | 0.780–0.833 | <0.0001 | <0.0001 | <0.0001 | |||
| PVD | 0.973 | 0.960–0.983 | <0.0001 | 0.8743 | 91.83 | 95.60 | 0.775 | 0.745–0.802 | <0.0001 | 0.830 | 0.804–0.855 | <0.0001 | <0.0001 | <0.0001 | |||
| ERM | 0.955 | 0.940–0.968 | <0.0001 | 0.8552 | 91.84 | 93.68 | 0.704 | 0.673–0.734 | <0.0001 | 0.759 | 0.730–0.787 | <0.0001 | <0.0001 | <0.0001 | |||
| SRF | 0.956 | 0.940–0.968 | <0.0001 | 0.8450 | 94.87 | 89.63 | 0.756 | 0.727–0.784 | <0.0001 | 0.833 | 0.807–0.857 | <0.0001 | <0.0001 | = 0.0003 | |||
| CNV | 0.983 | 0.972–0.990 | <0.0001 | 0.9556 | 97.22 | 98.34 | 0.860 | 0.835–0.882 | <0.0001 | 0.917 | 0.896–0.934 | <0.0001 | = 0.0007 | = 0.0227 | |||
| Retinoschisis | 0.926 | 0.906–0.942 | <0.0001 | 0.7456 | 92.23 | 82.32 | 0.727 | 0.696–0.756 | <0.0001 | 0.739 | 0.708–0.767 | <0.0001 | <0.0001 | <0.0001 | |||
| Drusen | 0.891 | 0.868–0.911 | <0.0001 | 0.7222 | 92.10 | 80.12 | 0.728 | 0.698–0.758 | <0.0001 | 0.803 | 0.775–0.828 | <0.0001 | <0.0001 | <0.0001 | |||
| CME | 0.997 | 0.991–0.999 | <0.0001 | 0.9537 | 96.43 | 98.94 | 0.732 | 0.702–0.761 | <0.0001 | 0.875 | 0.851–0.896 | <0.0001 | <0.0001 | = 0.0028 | |||
| Exudation | 0.944 | 0.927–0.959 | <0.0001 | 0.7856 | 89.57 | 88.99 | 0.657 | 0.624–0.688 | <0.0001 | 0.793 | 0.764–0.819 | <0.0001 | <0.0001 | <0.0001 | |||
| MH | 0.948 | 0.931–0.962 | <0.0001 | 0.8931 | 90.48 | 98.83 | 0.785 | 0.756–0.811 | <0.0001 | 0.857 | 0.832–0.880 | <0.0001 | = 0.0020 | = 0.0376 | |||
| Ellipsoid zone disruption | 0.935 | 0.916–0.950 | <0.0001 | 0.8000 | 87.65 | 92.35 | 0.704 | 0.672–0.734 | <0.0001 | 0.734 | 0.703–0.763 | <0.0001 | <0.0001 | <0.0001 | |||
| FCE | 0.967 | 0.953–0.978 | <0.0001 | 0.9058 | 91.18 | 99.41 | 0.764 | 0.735–0.792 | <0.0001 | 0.808 | 0.781–0.834 | <0.0001 | <0.0001 | = 0.0001 | |||
| Choroid atrophy | 0.959 | 0.943–0.971 | <0.0001 | 0.8288 | 93.62 | 89.26 | 0.718 | 0.687–0.748 | <0.0001 | 0.799 | 0.771–0.825 | <0.0001 | <0.0001 | <0.0001 | |||
| Retinal hemorrhage | 0.991 | 0.982–0.996 | <0.0001 | 0.9631 | 100.00 | 96.31 | 0.744 | 0.714–0.773 | 0.0034 | 0.798 | 0.770–0.824 | 0.0003 | = 0.0022 | = 0.0136 | |||