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. 2022 Nov 17;14:174. doi: 10.1186/s13195-022-01113-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Study overview. A–C Cerebrospinal fluid (CSF) and plasma sampled within subject at or near the same time point from control (n=18) and AD (n=18) subjects was analyzed by three proteomic platforms: untargeted tandem mass tag mass spectrometry (TMT-MS) on both undepleted fluid and fluid depleted of the top 14 most abundant proteins; proximity extension assay (PEA) targeting 1160 unique proteins (Olink 1196); and a modified aptamer-based assay targeting 6596 unique proteins (SomaLogic 7000). B Matched CSF and plasma from 90 control and 118 Parkinson’s disease (PD) subjects were analyzed by PEA targeting 1536 unique proteins (Olink 1536). C Protein co-expression networks for CSF and plasma were separately constructed using the union measurements from all three platforms in each biofluid. Networks were compared across biofluids and with an AD brain network previously described in Johnson et al. [2]