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. 2022 Nov 17;14:174. doi: 10.1186/s13195-022-01113-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Cross-fluid eigenproteins. A–D CSF protein network module eigenproteins and their synthetic eigenproteins in plasma were compared between control and AD groups (A). B Relative eigenprotein levels were compared within subject across fluids in control and AD cases. The difference in average slope (Z_slope) between AD and control was calculated for each module. C Plasma protein network module eigenproteins and their synthetic eigenproteins in CSF were compared between control and AD groups. D Relative eigenprotein levels were compared within subject across fluids in control and AD cases. n=18 control, 17 AD for all analyses. Selected modules shown include those that had significant AD trait relationships and were also preserved in CSF by at least one preservation method. Boxplots, within subject cross-fluid eigenproteins, and Z_slope calculations for all CSF and plasma modules are provided in Additional file 1: Extended Data. Differences between groups were assessed by t test