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. 2022 Nov 17;14:174. doi: 10.1186/s13195-022-01113-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Differential protein abundance in AD by platform in CSF and plasma. A Differential protein abundance at the individual protein level between AD and control cases on the SomaScan (left), Olink (center), and TMT-MS Depleted (right) platforms, in CSF (top) and plasma (bottom). AD-control values less than 0 indicate decreased levels in AD, and values greater than 0 indicate increased levels in AD. Proteins that are above the dashed red line are significantly altered in AD by t test at p<0.05. Proteins are colored by the brain co-expression module in which they reside, as described in Johnson et al. [2] B Overlap of differential protein expression in CSF and plasma across the three platforms. Overlap includes all commonly and uniquely measured proteins in each platform and is restricted to unique gene symbols (i.e., excluding gene isoforms or redundant aptamers, which are included in A)