Table 3.

Estimated model parameters of safety analysis.

AEs	Intercept	ω2 of intercept	Slope			ω2
			Oxycodone	Oxymorphone	Tramadol	Oxycodone	Oxymorphone	Tramadol
Constipation	5.32	0.0602	0.0470	0.0141	0.00460	0.0000100	0.0000100	0.0000100
Nausea	8.67	0.0501	0.0390	0.0248	0.00395	0.149	0.0137	0.00430
Vomiting	2.67	0.0129	0.0409	0.0305	0.00510	0.111	0.0000100	0.136
Dizziness	5.85	0.0359	0.0351	0.0183	0.00390	0.0515	0.00400	0.0000100
Headache	7.59	0.0787	−0.000100	0.00380	0.000100	0.00570	0.0333	3.01
Somnolence	3.76	0.0846	0.0405	0.0190	0.00431	0.0000100	0.0000100	0.126
Xerostomia	2.47	0.117	0.0229	0.0164	0.0036	0.0000135	0.0000100	0.0000100
Pruritus	2.23	0.0248	0.0475	0.0259	0.00397	0.0000100	0.0000100	0.0000100
Fatigue	2.61	0.00220	0.0260	0.00960	0.00320	0.0788	0.0000100	0.0000100