Table 4.
Summary of predicted AEs at compound recommended dose range and ED50.
| AEs | Oxycodone | Oxymorphone | Tramadol | |||
|---|---|---|---|---|---|---|
| 20–160 mg/day | ED50(47.0) | 10–80 mg/day | ED50(83.9) | 100–300 mg/day | ED50(247) | |
| Constipation | 12.6 – 99.1% | 33.9 % | 6.08 – 14.8 % | 15.5 % | 8.21 – 18.5% | 15.0 % |
| Nausea | 19.0 – 99.3% | 44.3 % | 10.9 – 41.5 % | 43.9 % | 12.4 – 23.8 % | 20.2 % |
| Vomiting | 6.40 – 97.6 % | 19.0 % | 3.59 – 23.9 % | 26.2 % | 4.69 – 13.7 % | 10.4 % |
| Dizziness | 11.5 – 65.8 % | 26.1 % | 6.95 – 21.3 % | 22.5 % | 8.40 – 16.7 % | 14.0 % |
| Somnolence | 8.07 – 96.2 % | 20.8 % | 4.51 – 15.2 % | 16.1 % | 5.99 – 14.5 % | 11.6 % |
| Headache | 7.57 – 7.44 % | 7.55 % | 7.87 – 10.1 % | 10.3 % | 8.47 – 10.5 % | 9.94 % |
| Pruritus | 5.56 – 97.9 % | 17.5 % | 2.87 – 15.3 % | 16.7 % | 3.28 – 7.00 % | 5.73 % |
| Xerostomia | 3.85 – 49.7 % | 6.92 % | 2.90 – 8.60 % | 9.12 % | 3.52 – 7.04 % | 5.88 % |
| Fatigue | 4.50 – 70.8 % | 9.15 % | 2.87 – 5.46 % | 5.66 % | 3.55 – 6.46 % | 5.52 % |