. 2022 Nov 1;7(45):41775–41782. doi: 10.1021/acsomega.2c06130

Table 2. Spearman Correlation Coefficients between Four Aromatic Amines and Three Dose Markers on Day 3 for Users of five Tobacco/Nicotine Products (Statistically Significant Correlations Coefficients Are Highlighted in Gray).

	CC			EC			HTP			NRT			OT
biomarker	Cons^a	Nequ^b	CotP^c	Cons^a	Nequ^b	CotP^c	Cons^a	Nequ^b	CotP^c	Cons^a	Nequ^b	CotP^c	Cons^a	Nequ^b	CotP^c
o-Tol (ng/day)	0.94***	0.95***	0.87**	0.22	0.01	–0.44	0.48	0.72*	0.20	0.15	0.49	–0.15	0.43	0.33	0.06
2-AN (ng/day)	0.92***	0.95***	0.93***	–0.23	–0.41	–0.57	0.56(*)	0.68*	0.27	0.78*	0.87**	0.64	0.10	0.19	–0.27
3-ABP (ng/day)	0.86**	0.93***	0.86**	0.26	0.21	0.08	0.62(*)	0.54	0.38	0.77*	0.48	0.29	–0.14	0.27	–0.15
4-ABP (ng/day)	0.92**	0.92**	0.90**	0.37	0.22	–0.25	0.50	0.36	0.16	0.58	0.69	0.39	–0.05	0.10	–0.21

Consumption recorded for Day 3: CC: cig/day, EC: mL of e-liquid/day (average of 3 study days), HTP: sticks/day, NRT: pieces of nicotine gum/day (N = 8) of 10, 2 subjects used nicotine inhalators, OT: g/day.

Nicotine equivalents (Nequ) excreted on Day 3, mg/day.

Cotinine in plasma, plasma sample derived from the blood samples drawn on Day 3 at 5 pm, ng/mL.

Statistical significance levels: *p < 0.05; **p < 0.01; ***p < 0.001; (*) borderline significance, p < 0.10.