Table 2. MAO-A and -B Inhibitory Activities of the Synthesized Compounds.
| MAO-A | MAO-B | MAO-A | MAO-B | ||
|---|---|---|---|---|---|
| IC50 (μM) | IC50 (μM) | IC50 (μM) | IC50 (μM) | ||
| benzophenones | isoindolinones | ||||
| 15 | 11.0 | 71.9 | 6 | 100.0 | 66.8 |
| 16 | 62.1 | n.d. | 11 | n.d. | n.d. |
| 17 | n.d. | n.d. | 23 | n.d. | n.d. |
| 19 | n.d. | n.d. | 28 | n.d. | n.d. |
| 21 | 47.0 | 61.6 | 29 | 75.4 | n.d. |
| 25 | n.d. | n.d. | 30 | 17.8 | 15.8 |
| 26 | n.d. | n.d. | 35 | n.d. | n.d. |
| 27 | n.d. | n.d. | 36 | 31.9 | 38.4 |
| 31 | 14.8 | 43.7 | 41 | 22.2 | n.d. |
| 32 | 34.1 | 53.6 | |||
| 33 | 27.5 | n.d. | phthalides | ||
| 34 | 24.8 | n.d. | 12 | n.d. | 52.8 |
| 37 | 52.2 | 18.6 | 18 | n.d. | n.d. |
| 38 | 20.6 | 94.3 | 20 | 38.5 | 38.9 |
| 39 | n.d. | n.d. | 22 | 86.3 | 16.4 |
| 40 | n.d. | n.d. | |||
| pargylinea | 4.0 | 1.5 |
a
Pargyline was used as a positive control. n.d. means > 100 μM.