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Assessment and prediction methodology of multi-ENP mixtures. (A) Schematic framework for the methodology. (B) Network diagram of association rules of ENPs in binary mixtures combined with the assessment methods for their joint toxicity (CA, concentration addition; IA, independent action; TU, toxic unit). (C) Scheme of machine-learning- or deep-learning-based QSAR approach used for the ecotoxicity prediction of the mixtures of individual ENPs.
