Table 2.

Incidence of any and all musculoskeletal morbidities among adults with and without SCI with one-year clean enrollment period.

Spinal Cord Injury	^† No Outcome at Baseline
Spinal Cord Injury	Case/Denominator	Control/Denominator
Any Musculoskeletal	2518/3057 (82.4%)^*	511657/1077396 (47.5%)
Osteoarthritis	2659/6620 (40.2%)^*	249195/1342834 (18.6%)
Osteoporosis	1760/7338 (24.0%)^*	88662/1421643 (6.2%)
Pathologic fracture	1543/7648 (20.2%)^*	20965/1469029 (1.4%)
Disorders of muscle, joint, ligaments, tendons, and connective tissues	3375/4382 (77.0%)^*	514011/1163784 (44.2%)
Sarcopenia and weakness	2540/8177 (31.1%)^*	90152/1456285 (6.2%)
Myalgia	1310/8311 (15.8%)^*	119512/1422838 (8.4%)
Rheumatoid arthritis, myositis, and musculoskeletal infections	414/8724 (4.7%)^*	29099/1455696 (2.0%)

P<.01 and standard mean difference (SMD) ≥0.2

^†

Denominators for both cases and controls reflect a one-year clean period during their enrollment for the specific condition. For instance, among cases (SCI), there exist 6,620 patients whose first year of enrollment had no evidence of osteoarthritis; therefore, inferred incident osteoarthritis could be estimated for this subset of the full SCI cohort. As a result, all patient cohorts’ denominators dynamically change conditional on the incident outcome being measured to ensure a clean period in the first year of enrollment.