TABLE 2.
Association Between the FI and Mortality in Older Cancer Survivors and Those Without a Cancer History
| FI | No. of Deaths/Total | Person-Years | Deaths per 100 Person-Years (95% CI) | cHR (95% CI) | aHR (95% CI)a | aHR (95% CI)b |
|---|---|---|---|---|---|---|
|
| ||||||
| Cancer survivors (n = 2050) | ||||||
| ≤0.10 | 18/121 | 963.8 | 1.9 (1.2–3.0) | REF | REF | REF |
| >0.10 to 0.21 | 198/783 | 5742.3 | 3.4 (3.0–4.0) | 1.92 (1.19–3.11) | 1.39 (0.86–2.27) | 1.58 (0.89–2.80) |
| >0.21 | 522/1146 | 6940.7 | 7.5 (6.9–8.2) | 4.49 (2.80–7.18) P trend < .01 |
2.80 (1.73–4.53) P trend < .01 |
3.41 (1.96–5.94) P trend < .01 |
| No cancer history (n = 9474) | ||||||
| ≤0.10 | 128/1045 | 8843.2 | 1.4 (1.2–1.7) | REF | REF | REF |
| >0.10 to 0.21 | 757/3894 | 31,088.5 | 2.4 (2.3–2.6) | 1.73 (1.43–2.09) | 1.38 (1.14–1.66) | 1.28 (1.05–1.56) |
| >0.21 | 1636/4535 | 30,577.3 | 5.4 (5.1–5.6) | 4.03 (3.37–4.83) P trend < .01 |
2.75 (2.29–3.32) P trend < .01 |
2.71 (2.23–3.29) P trend < .01 |
Abbreviations: aHR, adjusted hazard ratio; cHR, crude hazard ratio; CI, confidence interval; FI, frailty index; REF, reference.
a
The multivariable Cox model adjusted for the following: age, sex, race, education, marital status, body mass index, smoking, alcohol drinking, protein and energy consumption, age at cancer diagnosis (only for participants with a cancer history), history of more than 1 cancer (only for participants with a cancer history), and survey year.
b
The multivariable model corrected for the sampling weight and adjusted for the same set of covariates as the main model.