TABLE 3.

Association Between Frailty (FI > 0.21) and All-Cause Mortality in Subgroups Defined by Study Covariates

	Cancer Survivors (n = 2050)		No Cancer History (n = 9474)
	No. of Deaths/Total	aHR (95% CI)	No. of Deaths/Total	aHR (95% CI)
Age
<75 y	274/1160	2.62 (2.00–3.43)	1141/6707	2.25 (1.99–2.54)
≥75 y	464/890	1.59 (1.27–1.97) P interaction < .01	1380/2767	2.05 (1.82–2.31) P interaction = .13
Sex
Female	305/978	2.46 (1.85–3.28)	1120/4842	2.18 (1.91–2.49)
Male	433/1072	1.89 (1.53–2.33) P interaction = .19	1401/4632	2.03 (1.82–2.27) P interaction = .46
Race
White	581/1536	2.06 (1.70–2.50)	1510/4817	2.12 (1.89–2.37)
Non-White	157/514	2.00 (1.38–2.90) P interaction = .89	1011/4657	2.05 (1.79–2.34) P interaction = .67
BMI
<30 kg/m2	541/1375	1.92 (1.59–2.33)	1773/6041	2.07 (1.88–2.29)
≥30 kg/m2	197/675	3.00 (2.04–4.40) P interaction = .06	748/3433	2.16(1.83–2.55) P interaction = .85
Alcohol drinking
No	256/689	2.08 (1.54–2.80)	955/3460	2.30 (1.99–2.65)
Yes	482/1361	2.15 (1.75–2.64) P interaction = .88	1566/6014	2.00 (1.80–2.23) P interaction = .10
Protein intake
<68.1 g/d	413/1016	2.18 (1.73–2.76)	1530/5147	2.10 (1.88–2.35)
≥68.1 g/d	325/1034	1.97 (1.54–2.51) P interaction = .68	991/4327	2.09 (1.83–2.38) P interaction = .93
Energy intake
<1735.5 kcal/d	404/1024	2.08 (1.65–2.63)	1508/5208	2.11 (1.88–2.36)
≥1735.5 kcal/d	334/1026	2.04 (1.60–2.60) P interaction = .96	1013/4266	2.09 (1.83–2.39) P interaction = .80

Abbreviations: aHR, adjusted hazard ratio; BMI, body mass index; CI, confidence interval; FI, frailty index.

The models adjusted for the same sets of covariates as those in Table 2 except for the ones used for stratification.