TABLE 1.
Association results for the top hit in the discovery stage and sentinel variants with significant and consistent effects in the discovery and replication phases, and the meta‐analysis across both phases
| ID a | rsID | Closest gene | Discovery | Replication | Meta‐analysis (discovery and replication) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | Cochran's Q p | OR (95% CI) | p | Cochran's Q p | OR (95% CI) | p | Cochran's Q p | |||
| 1:101210560:C:T | rs12091010 | EXTL2 | 0.82 (0.75–0.90) | 9.05E‐06 | 4.83E‐01 | 0.89 (0.82–0.97) | 5.35E‐03 | 4.92E‐01 | 0.86 (0.81–0.91) | 4.23E‐07 | 4.47E‐01 |
| 5:22659406:T:C | rs6888198 | CDH12 | 1.37 (1.23–1.54) | 1.95E‐08 | 5.82E‐01 | 1.02 (0.90–1.15) | 7.72E‐01 | 7.18E‐01 | 1.24 (1.05–1.45) | 2.41E‐06 | 1.89E‐02 |
| 10:91376299:T:C | rs943126 | PANK1 | 0.85 (0.78–0.92) | 3.10E‐05 | 8.01E‐02 | 0.92 (0.86–0.98) | 1.30E‐02 | 3.87E‐01 | 0.89 (0.85–0.94) | 4.93E‐06 | 7.91E‐02 |
Abbreviations: 95% CI, 95% confidence interval; OR, odds ratio; p, p‐value.
a
The variant identifier corresponds to chromosomal position (hg19) followed by non‐tested allele and tested allele.