TABLE 3.
Results from the meQTL analysis in whole blood in the GALA II and SAGE studies for genome‐wide significant hit in the discovery and two SNPs that were replicated
| SNP‐CpG pair | Position (hg19) | Closest genes | Mexican Americans | Puerto Ricans | African Americans | Meta‐analysis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coef | SE | p | Coef | SE | p | Coef | SE | p | Coef | SE | p | Cochran's Q p | Storey q | |||
| rs943126‐cg26800131 | 91574784 | KIF20B | −0.21 | 0.11 | 2.99E‐04 | −0.07 | 0.04 | 6.99E‐02 | −0.07 | 0.04 | 8.87E‐02 | −0.18 | 0.10 | 1.85E‐06 | 4.45E−03 | 9.95E‐04 |
| rs943126‐cg14920044 | 91296311 | SLC16A12 | 0.09 | 0.05 | 9.77E‐02 | 0.24 | 0.06 | 1.68E‐05 | 0.12 | 0.06 | 4.68E‐02 | 0.15 | 0.03 | 4.61E‐06 | 1.24E‐01 | 1.24E‐03 |
| rs943126‐cg20654695 | 91444521 | KIF20B/PANK1 | −0.10 | 0.08 | 2.12E‐01 | −0.06 | 0.04 | 9.04E‐02 | −0.15 | 0.03 | 2.04E‐05 | −0.10 | 0.02 | 9.96E‐06 | 1.98E−01 | 1.79E‐03 |
| rs943126‐cg25770176 | 91405685 | PANK1 | −0.09 | 0.03 | 1.43E‐03 | 0.00 | 0.09 | 2.78E‐01 | −0.07 | 0.02 | 3.00E‐03 | −0.07 | 0.02 | 1.86E‐05 | 1.49E−01 | 2.50E‐03 |
| rs12091010‐cg05612904 | 101491636 | DPH5 | −0.07 | 0.04 | 6.99E‐02 | −0.21 | 0.11 | 2.99E‐04 | −0.09 | 0.04 | 2.72E‐02 | −0.10 | 0.02 | 2.31E‐05 | 9.52E−02 | 1.20E‐02 |
| rs943126‐cg00475140 | 91404454 | PANK1 | −0.21 | 0.07 | 1.39E‐03 | −0.13 | 0.08 | 1.05E‐01 | −0.19 | 0.09 | 3.19E‐02 | −0.18 | 0.04 | 4.28E‐05 | 5.25E−01 | 4.60E‐03 |
| rs943126‐cg15620114 | 91296457 | SLC16A12 | 0.09 | 0.08 | 2.64E‐01 | 0.27 | 0.09 | 3.87E‐03 | 0.20 | 0.08 | 7.76E‐03 | 0.18 | 0.05 | 1.53E‐04 | 5.70E−01 | 1.32E‐02 |
| rs943126‐cg04957662 | 91411382 | KIF20B/PANK1 | −0.34 | 0.79 | 6.69E‐01 | −1.16 | 0.29 | 1.33E‐04 | −0.77 | 0.26 | 2.89E‐03 | −1.02 | 0.27 | 1.72E‐04 | 3.14E−01 | 1.32E‐02 |
Abbreviations: Coef, Coefficient of the regression; p, p‐value; SE, standard error; Storey q, Storey q‐value. Bold numbers corresponds to values less than .05 for both Storey q and p.