4. Sensitivity in asymptomatic populations (IgG, IgM, total Ab).
|
Test groups (true positives/COVID cases) Sensitivity (95% CI) |
|||
| Target | Days 0‐14 post‐RT‐PCR‐positive | Days > 14 post‐RT‐PCR‐positive | Timing unknown |
| IgG | 9 (96/208) | 10 (85/111) | 9 (82/155) |
|
49.8 (25.7, 73.9) |
78.2 (61.5, 88.9) |
28.4 (10.7, 56.9) |
|
| IgM | 6 (55/144) | 1 (7/27) | 2 (22/28) |
|
42.9 (19.5, 70.0) |
25.9a (11.1, 46.3)b |
78.6 (59.8, 90.0) |
|
| IgA | 3 (41/64) | 1 (27/27) | ‐ |
|
64.1 (51.7, 74.8) |
100a (87.2, 100)c |
‐ | |
| IgG/IgM | 2 (28/68) | ‐ | 2 (51/81) |
|
41.2 (30.2, 53.1) |
‐ |
63.0 (52.0, 72.7) |
|
| Total antibodies (Ab) | 4 (35/52) | 2 (33/38) | 2 (6/20) |
|
67.1 (45.8, 83.1) |
95.5 (7.2, 100) |
30.0 (14.2, 52.7) |
|
Ab: antibody
CI: confidence interval
RT‐PCR: reverse transcription polymerase chain reaction
aEstimates and confidence intervals by summing the counts of true positive and false negative across 2 x 2 tables
b95% exact binomial confidence interval
c97.5% one‐sided exact binomial confidence interval