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. 2022 Nov 17;2022(11):CD013652. doi: 10.1002/14651858.CD013652.pub2
  Test groups (true negatives/non‐COVID cases)
Specificity (95% CI)
Target Pre‐pandemic Mixed groups Other groups
IgA a 17 (1603/1711) 6 (5573/5949)  
  93.8
(90.5, 96.0)
91.9
(68.5, 98.3)
Suspected of COVID‐19
4 (310/385)
91.5
(84.0, 95.7)
      Current untested
2 (197/204)
96.0 (89.4, 98.6)
IgA/IgG a 2 (101/106) 3 (197/256)  
  97.6
(66.8, 99.9)
77.8
(68.8, 84.7)
 
IgA/IgM 1 (26/56)    
  46.4a
(33.0, 60.3)*
   
aP value for comparison across week to week 5 obtained using ‘melogit’; both P < 0.0001
bEstimates and confidence intervals by summing the counts of true positive and false negative across 2 x 2 tables
*95% exact binomial confidence interval
**97.5% one‐sided exact binomial confidence interval
CI: confidence interval