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. 2022 Nov 17;2022(11):CD013652. doi: 10.1002/14651858.CD013652.pub2
Test name Test name Pre‐pandemic Suspected of COVID‐19 Current RT‐PCR‐negative Current untested Other/mixed unclear Cross‐reactivity/confounder panels
Test brand Test brand Specificity (95% CI) Test groups (true negatives/non‐COVID cases)
ELISA
Beijing Wantai Wantai ELISA Total‐Ab assay 8 (2009/2020) 1 (50/50)   1 (300/300) 1 (97/100) 2 (130/130)
    99.5
(99.0, 99.7)
100a
(92.9, 100)**
  100a
(98.8, 100)**
97.0a
(91.5, 99.4)*
100a
(97.2, 100)**
Bio‐Rad Laboratories Novel coronavirus COVID‐19 Total‐Ab assay           1 (28/28)
              100a
(87.7, 100)**
CLIA
Ortho Clinical Vitros (VITROS) Anti‐SARS‐Cov‐2 Total assay Total‐Ab 2 (995/997)   1 (57/57)     2 (168/169)
    99.8
(98.5, 100)
  100a
(93.7, 100)**
    99.4
(95.9, 99.9)
Roche Diagnostics Elecsys anti‐SARS‐CoV‐2 antibody assay 25 (5569/5579) 3 (331/336) 4 (307/307) 2 (1029/1029) 1 (26/26)
2 (99/99)
13 (836/839)
    99.8
(99.7, 99.9)
98.5
(96.5, 99.4)
100a
(98.8, 100)**
100a
(99.6, 100)**
100a
(96.3, 100)**
99.8
(97.6, 100)
Siemens Healthcare Siemens Atellica Total‐Ab assay 6 (2435/2439)         3 (210/210)
    99.9
(99.3, 100)
        100a
(98.3, 100)**
Siemens Healthcare Siemens Vista Total‐Ab assay 1 (596/596)         1 (35/35)
    100a
(99.4, 100)**
        100a
(90.0, 100)**
Watmind Medical SARS‐CoV‐2 Ab Diagnostic Test Kit 1 (41/50)          
    82.0a
(68.6, 91.4)*
         
Xiamen Wantai Total Ab CMIA   1 (231/234)        
      98.7a
(96.3, 99.7)*
       
Xiamen InnoDx Novel coronavirus (2019‐nCoV) antibody test kit Total‐Ab 1 (267/270)          
    98.9a
(96.8, 99.8)*
         
Other/unclear
Luminex SARS‐CoV‐2 MIA
Total Ab
1 (254/256)          
    99.2a
(97.2, 99.9)*
         
Vibrant America Vibrant COVID‐19 Ab Total‐Ab         1 (5250/5262)  
            99.8a
(99.6, 99.9)*
 
aEstimates and confidence intervals by summing the counts of true negative and false positive across 2 x 2 tables
*95% exact binomial confidence interval
**97.5% one‐sided exact binomial confidence interval
Ab: antibodyCI: confidence intervalsCLIA: chemiluminescence immunoassayELISA: enzyme‐linked immunosorbent assay MIA: magnetic immunoassay
RT‐PCR: reverse transcription polymerase chain reaction