Test name | Test name | Pre‐pandemic | Suspected of COVID‐19 | Current RT‐PCR‐negative | Current untested | Other/mixed unclear | Cross‐reactivity/confounder panels |
Test brand | Test brand | Specificity (95% CI) | Test groups (true negatives/non‐COVID cases) | ||||
ELISA | |||||||
Beijing Wantai | Wantai ELISA Total‐Ab assay | 8 (2009/2020) | 1 (50/50) | 1 (300/300) | 1 (97/100) | 2 (130/130) | |
99.5 (99.0, 99.7) |
100a (92.9, 100)** |
100a (98.8, 100)** |
97.0a (91.5, 99.4)* |
100a (97.2, 100)** |
|||
Bio‐Rad Laboratories | Novel coronavirus COVID‐19 Total‐Ab assay | 1 (28/28) | |||||
100a (87.7, 100)** |
|||||||
CLIA | |||||||
Ortho Clinical | Vitros (VITROS) Anti‐SARS‐Cov‐2 Total assay Total‐Ab | 2 (995/997) | 1 (57/57) | 2 (168/169) | |||
99.8 (98.5, 100) |
100a (93.7, 100)** |
99.4 (95.9, 99.9) |
|||||
Roche Diagnostics | Elecsys anti‐SARS‐CoV‐2 antibody assay | 25 (5569/5579) | 3 (331/336) | 4 (307/307) | 2 (1029/1029) | 1 (26/26) 2 (99/99) |
13 (836/839) |
99.8 (99.7, 99.9) |
98.5 (96.5, 99.4) |
100a (98.8, 100)** |
100a (99.6, 100)** |
100a (96.3, 100)** |
99.8 (97.6, 100) |
||
Siemens Healthcare | Siemens Atellica Total‐Ab assay | 6 (2435/2439) | 3 (210/210) | ||||
99.9 (99.3, 100) |
100a (98.3, 100)** |
||||||
Siemens Healthcare | Siemens Vista Total‐Ab assay | 1 (596/596) | 1 (35/35) | ||||
100a (99.4, 100)** |
100a (90.0, 100)** |
||||||
Watmind Medical | SARS‐CoV‐2 Ab Diagnostic Test Kit | 1 (41/50) | |||||
82.0a (68.6, 91.4)* |
|||||||
Xiamen Wantai | Total Ab CMIA | 1 (231/234) | |||||
98.7a (96.3, 99.7)* |
|||||||
Xiamen InnoDx | Novel coronavirus (2019‐nCoV) antibody test kit Total‐Ab | 1 (267/270) | |||||
98.9a (96.8, 99.8)* |
|||||||
Other/unclear | |||||||
Luminex | SARS‐CoV‐2 MIA Total Ab |
1 (254/256) | |||||
99.2a (97.2, 99.9)* |
|||||||
Vibrant America | Vibrant COVID‐19 Ab Total‐Ab | 1 (5250/5262) | |||||
99.8a (99.6, 99.9)* |
|||||||
aEstimates and confidence intervals by summing the counts of true negative and false positive across 2 x 2 tables *95% exact binomial confidence interval **97.5% one‐sided exact binomial confidence interval Ab: antibodyCI: confidence intervalsCLIA: chemiluminescence immunoassayELISA: enzyme‐linked immunosorbent assay MIA: magnetic immunoassay RT‐PCR: reverse transcription polymerase chain reaction |